Adhesion
| CSTコード |
包装 |
希望納入価格（円） |
国内在庫  |
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| #1002 | 100 μg | 16,000 | |
|
Catenin-beta抗体製品一覧
| 使用目的 | |
| β-Catenin (6B3) Rabbit mAb (#9582) およびβ-Catenin Antibody (Carboxy-terminal Antigen) Antibody (#9587) の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded breast carcinoma tissue using β-Catenin (6B3) Rabbit mAb #9582 in the presence of control peptide (left) or β-Catenin Blocking Peptide (right).
β-catenin is a key downstream effector in the Wnt signaling pathway (1). It is implicated in two major biological processes in vertebrates: early embryonic development (2) and tumorigenesis (3). CK1 phosphorylates β-catenin on Ser45. This phosphorylation event primes β-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3β destabilizes β-catenin by phosphorylating it at Ser33, Ser37 and Thr41 (7). Mutations in these phosphorylation sites, which result in the stabilization of β-catenin protein levels, have been found in many tumor cell lines (8).
-
Cadigan, K.M. and Nusse, R. (1997)
Genes Dev.
11, 3286-3305.
-
Wodarz, A. and Nusse, R. (1998)
Annu. Rev. Cell. Dev. Biol.
14, 59-88.
-
Polakis, P. (1999)
Curr. Opin. Genet. Dev.
9, 15-21.
-
Amit, S. et al. (2002)
Genes Dev.
16, 1066-1076.
-
Lin, C. et al. (2002)
Cell
108, 837-847.
-
Yanagawa, S. et al. (2002)
EMBO J.
21, 1733-1742.
-
Yost, C. et al. (1996)
Genes Dev.
10, 1443-1454.
-
Morin, P.J. (1997)
Science
275, 1787-1790.
