Wnt / Hedgehog / Notch
| CSTコード |
包装 |
希望納入価格 (円) |
国内在庫  |
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| #1007S | 100 μg | 16,000 | |
|
TCF1抗体製品一覧
| 使用目的 | |
| TCF1 (C63D9) Rabbit mAb (#2203) の反応をブロックし、抗体の特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma using TCF1 (C63D9) Rabbit mAb #2203 in the presence of control peptide (left) or TCF1 Blocking Peptide (right).
LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).
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Waterman, M.L. (2004) Cancer Metastasis Rev. 23, 41-52.
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Schilham, M.W. and Clevers, H. (1998) Semin. Immunol. 10, 127-132.
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Brantjes, H. et al. (2002) Biol. Chem. 383, 255-261.
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Reya, T. and Clevers, H. (2005) Nature 434, 843-850.
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Logan, C.Y. and Nusse, R. (2004) Annu. Rev. Cell Dev. Biol. 20, 781-810.
