Jak/Stat Pathway
Jak1 Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1013S | 100 μg | 16,000 | |
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Jak1抗体製品一覧
| 使用目的 | |
| Jak1 (6G4) Rabbit mAb （#3344）の反応をブロックし、抗体の反応特異性を確認するために使用 |
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Jak1 (6G4) Rabbit mAb #3344 in the presence of control peptide (left) or Jak1 Blocking Peptide (right).
Members of the Janus family of tyrosine kinases (Jak1, Jak2, Jak3, and Tyk2) are activated by ligands binding to a number of associated cytokine receptors (1). Upon cytokine receptor activation, Jak proteins become autophosphorylated and phosphorylate their associated receptors to provide multiple binding sites for signaling proteins. These associated signaling proteins, such as Stats (2), Shc (3), insulin receptor substrates (4), and focal adhesion kinase (FAK) (5), typically contain SH2 or other phospho-tyrosine-binding domains.
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Leonard, W.J. and O'Shea, J.J. (1998) Annu Rev Immunol 16, 293-322.
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Darnell, J.E. (1997) Science 277, 1630-5.
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VanderKuur, J. et al. (1995) J Biol Chem 270, 7587-93.
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Argetsinger, L.S. et al. (1995) J Biol Chem 270, 14685-92.
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Zhu, T. et al. (1998) J Biol Chem 273, 10682-9.
