NF-kappaB Signaling

Phospho-NF-κB p105 (Ser933) Blocking Peptide

 イイネ！(0) Phospho-NF-κB p105 (Ser933) Blocking Peptide Data Sheet PDF
CSTコード 包装
希望納入価格 (円)
国内在庫 i
2012年2月9日15時20分 現在
ご登録代理店情報 i
カスタマー情報にご登録いただいた代理店を表示しています。
ご登録代理店の変更はこちら。
#1021S100 μg16,000
ログインすると国内在庫状況がご確認いただけます。

NFkB-p105抗体製品一覧

用途
免疫組織染色
貯法
-20℃
使用目的
Phospho-NF-κB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific) （#4808）の反応をブロックし、抗体の反応特異性を確認するために使用
社内データ

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using Phospho-NF-kappaB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific) #4808 in the presence of control peptide (left) or Phospho-NF-kappaB p105 (Ser933) Blocking Peptide (right).

バックグラウンド

Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responses (1,2). There are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectively. Rel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcription. In unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteins (3-5). NF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expression (6-8). NIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which is then translocated to the nucleus (9-11).

  1. Baeuerle, P.A. and Henkel, T. (1994) Annu Rev Immunol 12, 141-79.
  2. Baeuerle, P.A. and Baltimore, D. (1996) Cell 87, 13-20.
  3. Haskill, S. et al. (1991) Cell 65, 1281-9.
  4. Thompson, J.E. et al. (1995) Cell 80, 573-82.
  5. Whiteside, S.T. et al. (1997) EMBO J 16, 1413-26.
  6. Traenckner, E.B. et al. (1995) EMBO J 14, 2876-83.
  7. Scherer, D.C. et al. (1995) Proc Natl Acad Sci USA 92, 11259-63.
  8. Chen, Z.J. et al. (1996) Cell 84, 853-62.
  9. Senftleben, U. et al. (2001) Science 293, 1495-9.
  10. Coope, H.J. et al. (2002) EMBO J 21, 5375-85.
  11. Xiao, G. et al. (2001) Mol Cell 7, 401-9.
使用例
製品をご使用いただいて研究を発表されましたら、ぜひお知らせください。
 
関連製品
4808   Phospho-NF-κB p105 (Ser933) (178F3) Rabbit mAb (IHC Specific)

本製品は試験研究用です。

Phospho-NF-κB p105 (Ser933) Blocking Peptide

Product Pathways

Tools

Applications