Apoptosis and Autophagy
Phospho-Bad (Ser112) Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1026S | 100 μg | 16,000 | |
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Bad抗体製品一覧
| 使用目的 | |
| Phospho-Bad (Ser112) (40A9) Rabbit mAb（#5284）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human prostate carcinoma, using Phospho-Bad (Ser 112) (40A9) Rabbit mAb (#5284) preincubated with control peptide (left) or Phospho-Bad (Ser 112) Blocking Peptide (right).
Bad is a proapoptotic member of the Bcl-2 family that promotes cell death by displacing Bax from binding to Bcl-2 and Bcl-xL (1,2). Survival factors, such as IL-3, inhibit the apoptotic activity of Bad by activating intracellular signaling pathways that result in the phosphorylation of Bad at Ser112 and Ser136 (2). Phosphorylation at these sites promotes binding of Bad to 14-3-3 proteins to prevent an association between Bad with Bcl-2 and Bcl-xl (2). Akt phosphorylates Bad at Ser136 to promote cell survival (3,4). Bad is phosphorylated at Ser112 both in vivo and in vitro by p90RSK (5,6) and mitochondria-anchored PKA (7). Phosphorylation of Ser155 in the BH3 domain by PKA plays a critical role in blocking the dimerization of Bad and Bcl-xL (8-10).
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