Cytoskeletal Signaling
Cox IV Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1034S | 100 μg | 16,000 | |
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COX4抗体製品一覧
| 使用目的 | |
| COX Ⅳ(3E11) Rabbit mAb （#4850）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded colon carcinoma, using COX IV Antibody #4844 in the presence of control peptide (left) or COX IV Blocking Peptide (right).
Cytochrome c oxidase (COX) is a hetero-oligomeric enzyme consisting of 13 subunits localized to the inner mitochondrial membrane (1-3). It is the terminal enzyme complex in the respiratory chain, catalyzing the reduction of molecular oxygen to water coupled to the translocation of protons across the mitochondrial inner membrane to drive ATP synthesis. The 3 largest subunits forming the catalytic core are encoded by mitochondrial DNA while the other smaller subunits, including COX IV, are nuclear-encoded. Deficiency in COX activity has been correlated with a number of human diseases (4). The COX IV antibody can be used effectively as a mitochondrial loading control.
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Ostermeier, C. et al. (1996) Curr. Opin. Struct. Biol. 6, 460-466.
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Capaldi, R.A. et al. (1983) Biochim. Biophys. Acta 726, 135-148.
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Kadenbach, B. et al. (2000) Free Radic. Biol. Med. 29, 211-221.
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Barrientos, A. et al. (2002) Gene 286, 53-63.
