Apoptosis and Autophagy
Survivin Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1037S | 100 μg | 16,000 | |
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Survivin抗体製品一覧
| 使用目的 | |
| Survivin (71G4) Rabbit mAb （#2808）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Survivin (71G4) Rabbit mAb #2808 in the presence of control peptide (left) or Survivin Blocking Peptide (right).
Survivin is a 16 kDa anti-apoptotic protein highly expressed during fetal development and cancer cell malignancy (1). Survivin binds and inhibits caspase-3, controlling the checkpoint in the G2/M-phase of the cell cycle by inhibiting apoptosis and promoting cell division (2,3). This regulatory process requires the phosphorylation of survivin at Thr34 by p34 cdc2 kinase (4). Gene targeting using a Thr34 phosphorylation-defective survivin mutant, as well as antisense survivin, have been shown to inhibit tumor growth (5,6).
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Reed, J.C. and Reed, S.I. (1999) Nature Cell Biol. 1, 199-200.
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Li, F. et al. (1998) Nature 396, 580-584.
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Li, F. et al. (1999) Nat. Cell Biol. 1, 461-466.
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O'Connor, D.S. et al. (2000) Proc. Natl. Acad. Sci. USA 97, 13103-13107.
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Olie, R.A. et al. (2000) Cancer Res. 60, 2805-2809.
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Grossman, D. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 635-640.
