Jak/Stat Pathway
| CSTコード |
包装 |
希望納入価格（円） |
国内在庫  |
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| #1038 | 100 μg | 16,000 | |
|
Stat1抗体製品一覧
| 使用目的 | |
| Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb (#9167) の反応をブロックし、抗体の特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded Non-Hodgkin's lymphoma using Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb #9167 in the presence of control peptide (left) or Phospho-Stat1 (Tyr701) Blocking Peptide (right).
The Stat1 transcription factor is activated in response to a large number of ligands (1) and is essential for responsiveness to IFN-α and IFN-γ (2,3). Phosphorylation of Stat1 at Tyr701 induces Stat1 dimerization, nuclear translocation and DNA binding (4). Stat1 protein exists as a pair of isoforms, Stat1α (91 kDa) and the splice variant Stat1β (84 kDa). In most cells, both isoforms are activated by IFN-α, but only Stat1α is activated by IFN-γ. The inappropriate activation of Stat1 occurs in many tumors (5). In addition to tyrosine phosphorylation, Stat1 is also phosphorylated at Ser727 through a p38 mitogen-activated protein kinase (MAPK)-dependent pathway in response to IFN-α and other cellular stresses (6). Serine phosphorylation may be required for the maximal induction of Stat1-mediated gene activation.
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Heim, M.H. (1999)
J. Recept. Signal. Transduct. Res.
19, 75-120.
-
Durbin, J.E. et al. (1996)
Cell
84, 443-450.
-
Meraz, M.A. et al. (1996)
Cell
84, 431-442.
-
Ihle, J.N. et al. (1994)
Trends Biochem. Sci.
19, 222-227.
-
Frank, D.A. (1999)
Mol. Med.
5, 432-456.
-
Wen, Z. et al. (1995)
Cell
82, 241-250.
