MAP Kinase Signaling
Phospho-MAPKAPK-2 (Thr334) Blocking Peptide
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イイネ！(1)
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| CSTコード |
包装 |
希望納入価格 (円) |
国内在庫  |
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| #1041S | 100 μg | 16,000 | |
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MAPKAPK-2抗体製品一覧
| 使用目的 | |
| Phospho-MAPKAPK-2 (Thr334) Antibody （#3041）およびPhospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb（#3007）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma, using Phospho-MAPKAPK-2 (Thr334) (27B7) Rabbit mAb (#3007) in the presence of control peptide (left), or Phospho-MAPKAPK-2 (Thr334) Blocking Peptide (right).
In response to cytokines, stress and chemotactic factors, MAP kinase-activated protein kinase 2 (MAPKAPK-2) is rapidly phosphorylated and activated. It has been shown that MAPKAPK-2 is a direct target of p38 MAPK (1). Multiple residues of MAPKAPK-2 are phosphorylated in vivo in response to stress. However, only four residues (Thr25, Thr222, Ser272 and Thr334) are phosphorylated by p38 MAPK in an in vitro kinase assay (2). Phosphorylation at Thr222, Ser272 and Thr334 appears to be essential for the activity of MAPKAPK-2 (2). Thr25 is phosphorylated by p42 MAPK in vitro, but is not required for the activation of MAPKAPK-2 (2).
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Rouse, J. et al. (1994) Cell 78, 1027-1037.
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Ben-Levy, R. et al. (1995) EMBO J. 14, 5920-5930.
