Translational Control
Phospho-4E-BP1 (Thr37/46) Blocking Peptide
|
イイネ！(0)
| 
|
| CSTコード |
包装 |
希望納入価格 (円) |
国内在庫  |
ご登録代理店情報 カスタマー情報にご登録いただいた代理店を表示しています。
ご登録代理店の変更は こちら。 |
| #1052S | 100 μg | 16,000 | |
|
4E-BP1抗体製品一覧
| 使用目的 | |
| Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb (#2855) の反応をブロックし、抗体の特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb #2855 in the presence of control peptide (left) or Phospho-4E-BP1 (Thr37/46) Blocking Peptide (right).
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5).
-
Pause, A. et al. (1994) Nature 371, 762-767.
-
Brunn, G.J. et al. (1997) Science 277, 99-101.
-
Gingras, A.C. et al. (1998) Genes Dev. 12, 502-513.
-
Fadden, P. et al. (1997) J. Biol. Chem. 272, 10240-10247.
-
Gingras, A.C. et al. (1999) Genes Dev. 13, 1422-1437.
