Translational Control
4E-BP1 Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1053S | 100 μg | 16,000 | |
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4E-BP1抗体製品一覧
| 使用目的 | |
| 4E-BP1 (53H11) Rabbit mAb (#9644) （ウエスタンブロッティング、免疫組織染色）および4E-BP1 Antibody (#9452) （ウエスタンブロッティング）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using 4E-BP1 (53H11) Rabbit mAb #9644 in the presence of control peptide (left) or 4E-BP1 Blocking Peptide (right).
Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5).
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Pause, A. et al. (1994) Nature 371, 762-767.
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Brunn, G.J. et al. (1997) Science 277, 99-101.
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Gingras, A.C. et al. (1998) Genes Dev. 12, 502-513.
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Fadden, P. et al. (1997) J. Biol. Chem. 272, 10240-10247.
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Gingras, A.C. et al. (1999) Genes Dev. 13, 1422-1437.
