Glucose / Energy Metabolism
Acetyl-CoA Carboxylase Blocking Peptide |
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| CSTコード | 包装 | 希望納入価格 (円) |
国内在庫  2012年2月9日15時20分 現在 |
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| #1062S | 100 μg | 16,000 | ログインすると国内在庫状況がご確認いただけます。
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| 用途 | |
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| 免疫組織染色 |
| 貯法 | |
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| -20℃ |
| 使用目的 | |
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| Acetyl-CoA Carboxylase (C83B10) Rabbit mAb (#3676) およびAcetyl-CoA Carboxylase Antibody （#3662）の反応をブロックし、抗体の反応特異性を確認するために使用 |
| 社内データ |
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IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using Acetyl-CoA Carboxylase (C83B10) Rabbit mAb #3676 in the presence of control peptide (left) or Acetyl-CoA Carboxylase Blocking Peptide #1062 (right).
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using Acetyl CoA Carboxylase Antibody in the presence of control peptide (left) or antigen-specific peptide (right).
| バックグラウンド |
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Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA (1). It is the key enzyme in the biosynthesis and oxidation of fatty acids (1). In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while the 280 kDa ACC2 (ACCβ) form is the main isoform in oxidative tissues (1,2). However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues (1,2). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (3). ACC is a potential target of anti-obesity drugs (4,5).
| 使用例 | |
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| 製品をご使用いただいて研究を発表されましたら、ぜひお知らせください。 |
| 関連製品 | |
|---|---|
| 3662 Acetyl CoA Carboxylase Antibody | |
| 3676 Acetyl-CoA Carboxylase (C83B10) Rabbit mAb |
本製品は試験研究用です。