Apoptosis and Autophagy
TRAF1 Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1066S | 100 μg | 16,000 | |
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TRAF1抗体製品一覧
| 使用目的 | |
| TRAF1 (45D3) Rabbit mAb (#4715) の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human tonsil using TRAF1 (45D3) Rabbit mAb #4715 in the presence of control peptide (left) or TRAF1 Blocking Peptide (right).
TRAFs (TNF receptor-associated factors) are a family of multifunctional adaptor proteins that bind to surface receptors and recruit additional proteins to form multiprotein signaling complexes capable of promoting cellular responses (1-3). Members of the TRAF family share a common carboxy-terminal "TRAF domain" which mediates interactions with associated proteins; many also contain amino-terminal Zinc/RING finger motifs. The first TRAFs identified, TRAF1 and TRAF2, were found by virtue of their interactions with the cytoplasmic domain of TNF-receptor 2 (TNFRII) (4). The six known TRAFs (TRAF1-6) act as adaptor proteins for a wide range of cell surface receptors and participate in the regulation of cell survival, proliferation, differentiation, and stress responses.
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Arch, R.H. et al. (1998) Genes Dev. 12, 2821-2830.
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Chung, J. Y. et al. (2002) J. Cell Sci. 115, 679-688.
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Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-6491.
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Rothe, M. et al. (1994) Cell 78, 681-692.
