Translational Control
BiP Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1084S | 100 μg | 16,000 | |
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BiP抗体製品一覧
| 使用目的 | |
| BiP (C50B12) Rabbit mAb (#3177) の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma using BiP (C50B12) Rabbit mAb #3177 in the presence of control peptide (left) or BiP Blocking Peptide (right).
Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).
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Wabl, M. and Steinberg, C. (1982) Proc. Natl. Acad. Sci. USA 79, 6976-6978.
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Haas, I.G. and Wabl, M. Nature 306, 387-389.
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Munro, S. and Pelham, H.R. (1986) Cell 46, 291-300.
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Kohno, K. et al. (1993) Mol. Cell Biol. 13, 877-890.
