Phosphatases
Phospho-cdc25C (Ser216) Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1190S | 100 μg | 16,000 | |
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Cdc25抗体製品一覧
| 使用目的 | |
| Phospho-cdc25C(Ser216) (63F9) Rabbit mAb (#4901）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human lymph node, using Phospho-cdc25C (Ser216) (63F9) Rabbit mAb #4901 in the presence of control peptide (left) or Phospho-cdc25C (Ser216) Blocking Peptide (right).
cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis (1). cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint (2). When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm preventing premature mitosis (3). The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage (4,5).
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Jessus, C. and Ozon, R. (1995) Prog. Cell Cycle Res. 1, 215-228.
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Peng, C.Y. et al. (1997) Science 277, 1501-1505.
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Kumagai, A. and Dunphy, W.G. (1999) Genes Dev. 13, 1067-1072.
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Blasina, A. et al. (1999) Curr. Biol. 9, 1-10.
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Furnari, B. et al. (1999) Mol. Biol. Cell 10, 833-845.
