Apoptosis and Autophagy
Bcl-xL Blocking Peptide
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1225S | 100 μg | 16,000 | |
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Bcl-xL抗体製品一覧
| 使用目的 | |
| Bcl-xL (54H6) Rabbit mAb (#2764) および Bcl-xL Antibody (#2762) の反応をブロックし、抗体の反応特異性を確認するために使用 |
Western Blotting

Western Blot analysis of extracts from Ramos and Raw cells using Bcl-xL (54H6) Rabbit mAb #2764 (left) or the same antibody preincubated with Bcl-xL Blocking Peptide (right).
Western Blotting

Western Blot analysis of extracts from Ramos and Raw cells using Bcl-xL Antibody #2762 (left) or the same antibody preincubated with Bcl-xL Blocking Peptide (right).
IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using Bcl-xL Antibody #2762 in the presence of control peptide (left) or Bcl-xL Blocking Peptide (right).
Bcl-xL prevents apoptosis through two different mechanisms: heterodimerization with an apoptotic protein inhibits its apoptotic effect (1,2) and formation of mitochondrial outer membrane pores help maintain a normal membrane state under stressful conditions (3). Bcl-xL is phosphorylated by JNK following treatment with microtubule-damaging agents such as paclitaxel, vinblastine and nocodazole (4,5).
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Adams, J.M. and Cory, S. (1998) Science 281, 1322-1326.
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Minn, A.J. et al. (1999) EMBO. J. 18, 632-643.
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Fan, M. et al. (2000) J. Biol. Chem. 275, 29980-29985.
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Poruchynsky, M.S. et al. (1998) Cancer Res. 58, 3331-3338.