Translational Control
Phospho-mTOR (Ser2448) Blocking Peptide
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イイネ！(1)
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| CSTコード |
包装 |
希望納入価格 (円) |
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| #1230S | 100 μg | 16,000 | |
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mTOR抗体製品一覧
| 使用目的 | |
| Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) （#2976）の反応をブロックし、抗体の反応特異性を確認するために使用 |
IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded human transitional epithelial carcinoma of the bladder, using Phospho-mTOR (Ser2448) (49F9) Rabbit mAb (IHC Specific) (#2976) in the presence of control peptide (left) or Phospho-mTOR (Ser2448) Blocking Peptide (right).
The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase (1-3) that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth (4,5). When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1 (6). These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481 (7,8). mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy (9).
No product specific background information is currently available for this product.
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