Vesicle Trafficking

Rab5 is a member of the Ras superfamily of small Rab GTPases. Rab5 is localized at the plasma membrane and early endosomes and functions as a key regulator of vesicular trafficking during early endocytosis (1). The conformational change between Rab5 GTP/GDP states is essential for its biological function as a rate limiting regulator at multiple steps during endocytosis (1,2). Rab5 exerts its function by interacting with several Rab5-specific effectors (1-3). These proteins form complexes with Rab5 on a specialized Rab domain of the endosome and promote recycling of Rab5-cargo targets between endosome and the plasma membrane.

1. Zerial, M. and McBride, H. (2001) Nat. Rev. Mol. Cell Biol. 2, 107-117.
2. van der Bliek, A.M. (2005) Nat. Cell Biol. 7, 548-550.
3. Haas, A.K. et al. (2005) Nat. Cell Biol. 7, 887-893.

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Rab5 Antibody

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