Adhesion

プロトコール

抗体比較

ポジティブコントロール

下記ステップについては、データシートの右側もあわせてご参照ください。

IHC-P: 抗体希釈液 / 抗原賦活化

Also known as plakoglobin, γ-catenin is a member of the Armadillo family of signaling molecules, which includes β-catenin and the Drosophila protein armadillo (1). This family of proteins is involved in Wnt signaling, which is important in embryonic development and in tumorigenesis (2-3). Although the two vertebrate proteins β- and γ-catenin display sequence homology, γ-catenin likely plays a role distinct from that of β-catenin (1, 4-6). γ-catenin localizes to desmosomes and adherens junctions, both sites of intercellular adhesion, and interacts with the cytoplasmic domains of classical and desmosomal cadherins. Interaction of γ- or β-catenin with α-catenin, desmoplakin and other junction proteins provides a link between intercellular junctions and the actin and intermediate filament cytoskeleton. Maintenance and/or modification of this link is vital for control of cell adhesion and migration (1). γ-catenin is modified by phosphorylation, affecting both adhesion and β-catenin dependent transcription (7), and by and O-glycosylation, affecting adhesion (8). Recent evidence suggests that γ-catenin regulates desmosomal adhesion in response to growth factor stimulation (9).

1. Zhurinsky, J. et al. (2000) J. Cell Sci. 113 ( Pt 18), 3127-3139.
2. Wodarz, A. and Nusse, R. (1998) Annu. Rev. Cell Dev. Biol. 14, 59-88.
3. Polakis, P. (1999) Curr. Opin. Genet. Dev. 9, 15-21.
4. Zhurinsky, J. et al. (2000) Mol. Cell Biol. 20, 4238-4252.
5. Charpentier, E. et al. (2000) J. Cell Biol. 149, 503-520.
6. Kolligs, F.T. et al. (2000) Genes Dev. 14, 1319-13131.
7. Miravet, S. et al. (2003) Mol. Cell Biol. 23, 7391-7402.
8. Hu, P. et al. (2006) J. Biol. Chem. 281, 12786-12791.
9. Yin, T. et al. (2005) J. Biol. Chem. 280, 40355-40363.

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γ-Catenin Antibody

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