Neuroscience
Stargazin Antibody
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| CSTコード |
包装 |
希望納入価格 (円) |
国内在庫  |
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| #2503S | 100 μL | 46,000 | |
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2503 の推奨プロトコール
最適な結果を得るために：Cell Signaling Technology (CST) 社は、各製品の推奨プロトコールを使用することを強くお薦めいたします。
推奨プロトコールはCST社内試験の徹底的なバリデーションに基づいて作成されておりますので、正確かつ再現性の高い結果が得られます。
注：各製品に最適化されたプロトコールをリンクしています。
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2503:
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Western Blotting
| 用途（希釈倍率） | |
| ウエスタンブロッティング(1:1,000) |
| 特異性・感度 | |
| 内在性レベルの総Stargazin タンパク質を検出します。 |
| 使用抗原 | |
| ヒトStargazin タンパク質由来の配列（合成ペプチド） |
Western Blotting
Western blot analysis of extracts from A431, CAD and PC12 cells using Stargazin Antibody.
Stargazin is a four-pass transmembrane protein related to VDCC (voltage dependent calcium channel) γ subunits and part of the TARP (transmembrane AMPA receptor regulatory protein) family of proteins. TARP proteins can form a complex with AMPA receptors (GluR1-4) and serve as integral auxiliary subunits (1-6).Interactions between stargazin and AMPA receptors are implicated in regulation of receptor surface expression, synaptic clustering and recycling, as well as increased receptor responsiveness to glutamate (1,2,5,6). Stargazin may play a role in the molecular mechanism of AMPAR-mediated inflammatory pain by taking part in signaling pathways that relay pain in the spinal cord (5). Because the protein also modulates the pharmacology of AMPA receptors, it enhances the effects of AMPAR potentiators that have therapeutic potential for a number of mental and neurodegenerative diseases (6).The carboxy terminus of the stargazin protein interacts with the PDZ domains of PSD95 and other membrane-associated guanylate kinase (MAGUK) family members, and together traffic AMPA receptors to the cell surface membrane, anchoring them to the postsynaptic site (1,7). Phosphorylation of stargazin by PKA on Thr321 inhibits this binding (3).
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Tomita, S. et al. (2005) Nature 435, 1052-1058.
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Priel, A. et al. (2005) J. Neurosci. 25, 2682-2686.
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Choi, J. et al. (2002) J. Biol. Chem. 277, 12359-12363.
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Osten, P. and Stern-Bach, Y. (2006) Curr. Opin. Neurobiol. 16, 275-280.
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Tao, F. et al. (2006) J. Neurosci. Res. 84, 867-873.
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Tomita, S. et al. (2006) Proc. Natl. Acad. Sci. USA 103, 10064-10067.
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Schnell, E. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 13902-13907.
PhosphoSitePlus®：
CACNG2