Jak/Stat Pathway

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SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain and a carboxy-terminal regulatory domain (1). SHP-1 removes phosphates from target proteins to down-regulate several tyrosine kinase regulated pathways. In hematopoietic cells, the N-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth (2). Over expression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation (3). Following ligand binding in myeloid cells, SHP-1 associates with IL-3R β chain and down regulates IL-3-induced tyrosine phosphorylation and cell proliferation (4). Because SHP-1 down regulates various proliferation pathways, SHP-1 is considered a potential tumor suppressor and angiogenesis regulator (5,6).

1. Yi, T.L. et al. (1992) Mol Cell Biol 12, 836-46.
2. Yi, T. et al. (1995) Blood 85, 87-95.
3. Keilhack, H. et al. (2001) J Cell Biol 152, 325-34.
4. Yi, T. et al. (1993) Mol Cell Biol 13, 7577-86.
5. Wu, C. et al. (2003) Gene 306, 1-12.
6. Bhattacharya, R. et al. (2008) J Mol Signal 3, 8.

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SHP-1 (C14H6) Rabbit mAb

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SHP-1 (C14H6) Rabbit mAbのCSTジャパン