Translational Control
FXR1 Antibody
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| CSTコード |
包装 |
希望納入価格 (円) |
国内在庫  |
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| #4173S | 100 μL | 46,000 | |
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FXR1抗体製品一覧
4173 の推奨プロトコール
最適な結果を得るために：Cell Signaling Technology (CST) 社は、各製品の推奨プロトコールを使用することを強くお薦めいたします。
推奨プロトコールはCST社内試験の徹底的なバリデーションに基づいて作成されておりますので、正確かつ再現性の高い結果が得られます。
注：各製品に最適化されたプロトコールをリンクしています。
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4173:
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Western Blotting
| 用途 (希釈倍率) | |
| ウェスタンブロッティング (1:1,000) |
| 特異性・感度 | |
| 内在性レベルのFXR1 タンパク質を検出します。 |
| 検出タンパク質の分子量 | |
| 78-80 kDa、82-84 kDa |
| 使用抗原 | |
| ヒトのFXR1 タンパク質の配列 (合成ペプチド) |
Western Blotting
Western blot analysis of various cell lines using FXR1 Antibody.
Western Blotting
Western blot analysis of extracts from mouse heart, human heart and human skeletal muscle tissue using FXR1 Antibody.
Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation (1). X-linked FMRP (FMR-1) and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome (1-3). Each of the fragile X proteins can self-associate as well as form heteromers with the other two related proteins (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). The Drosophila homolog of FMRP (dFMRP) associates with Argonaute 2 (Ago2) and Dicer and can coimmunoprecipitate with miRNA and siRNA (5). These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways. In addition, FMRP, FXR1 and FXR2 are components of stress granules (SG) and have been implicated in the translational regulation of mRNAs (6).
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Verkerk, A.J. et al. (1991) Cell 65, 905-14.
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Siomi, M.C. et al. (1995) EMBO J 14, 2401-8.
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Zhang, Y. et al. (1995) EMBO J 14, 5358-66.
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Caudy, A.A. et al. (2002) Genes Dev 16, 2491-6.
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Siomi, H. et al. (2004) Ment Retard Dev Disabil Res Rev 10, 68-74.
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Linder, B. et al. (2008) Hum Mol Genet 17, 3236-46.
PhosphoSitePlus®：
FXR1