#17433 CMTM4 Antibody
|CMTM4 Antibody recognizes endogenous levels of total CMTM4 protein. This antibody does not cross-react with CMTM6 protein.|
|Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu202 of human CMTM4 protein. Antibodies are purified by protein A and peptide affinity chromatography.|
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Western blot analysis of extracts from various cell lines using CMTM4 Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected (+) with constructs expressing Myc/DDK-tagged full-length human CMTM4 (CMTM4-Myc/DDK), Myc/DDK-tagged full-length mouse CMTM4 (CMTM4 mouse-Myc/DDK), Myc/DDK-tagged full-length human CMTM6 (CMTM6-Myc/DDK), Myc/DDK-tagged full-length mouse CMTM6 (CMTM6 mouse-Myc/DDK), using CMTM4 Antibody (upper), Myc-Tag (71D10) Rabbit mAb #2278 (middle), and β-actin (D6A8) Rabbit mAb #8457 (lower).
Immunoprecipitation of CMTM4 protein from SCLC-21H cell extracts. Lane 1 is 10% input, lane 2 is Rabbit (DA1E) mAb IgG XP® Isotype Control #3900, and lane 3 is CMTM4 Antibody. Western blot analysis was performed using CMTM4 Antibody.
CKLF-like MARVEL transmembrane domain-containing protein 4 (CMTM4) is a member of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (1). CMTM4 acts as a tumor suppressor in various malignancies, and regulates cell growth and transition through the cell cycle in HeLa cells (1-4). CMTM4 plays an important role in angiogenesis, enabling internalization of membrane-bound vascular endothelial cadherin at adherens junctions, mediating endothelial barrier function, and controlling vascular sprouting (5). In the immune system, CMTM4 acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1, an immune inhibitory ligand critical for immune tolerance to self and anti-tumor immunity (6-8). CMTM4 may also protect PD-L1 from being polyubiquitinated and targeted for degradation (8). Due to the roles of CMTM4 in the immune system and as a tumor suppressor, it is being investigated as a therapeutic target for the treatment of cancer.
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