#29623 MUC16 Antibody
|MUC16 antibody recognizes endogenous levels of total MUC16 protein.|
|Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MUC16 protein. Antibodies are purified by protein A and peptide affinity chromatography.|
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Western blot analysis of OVCAR3 and SK-OV-3 cell lysates using MUC16 antibody (upper) and α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower). As expected, SK-OV-3 cells are negative for MUC16 protein expression.
Mucins are a family of macromolecules that line and protect the respiratory epithelium from microbes and pollutants in the local environment. Of the family members that are known to date, some are produced in a cell type and tissue-specific manner, suggesting distinct biological roles for members. Some members polymerize after secretion to form gel-like substances that coat the epithelial layer (1). MUC16 is a member of the mucin family, which are a high molecular weight, O-glycosylatyed proteins that play an important role in forming mucous barrier (2) and are found on the apical surface of the epithelia. It contains an extracellular domain at its amino acid terminus, a large tandem repeat and a transmembrane domain with a short cytoplasmic domain. MUC16 has been linked to lung cancer (3), and ovarian cancer (4). It provides protective, lubricating barrier against particles and infectious agents at mucosal surfaces (5).
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