#38145 VISTA (D5L5T) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate)
|VISTA (D5L5T) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total VISTA protein.|
|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val291 of mouse VISTA protein.|
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VISTA (V-Domain Ig Suppressor of T Cell Activation) is a negative checkpoint control protein that regulates T cell activation and immune responses. VISTA, which contains a single Ig-like V-type domain, a transmembrane domain, and an intracellular domain, has sequence similarity to both the B7 and CD28 family members. Although primarily expressed by myeloid cells, VISTA is also expressed by CD4+, CD8+, and FoxP3+ T-cells. Thus, VISTA is described as both a ligand and a receptor (1-3). Blocking VISTA induces T-cell activation and proliferation, and potentiates disease severity in the EAE model (1). Furthermore, genetic deletion of VISTA in mice leads to spontaneous T-cell activation and chronic inflammation (4,5). In mouse models of cancer, neutralization of VISTA enhances T-cell proliferation and effector function and increases tumor infiltration, suggesting VISTA blockade could be an effective strategy for tumor immunotherapy (6,7).
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- Wang, L. et al. (2014) Proc Natl Acad Sci U S A 111, 14846-51.
- Liu, J. et al. (2015) Proc Natl Acad Sci U S A 112, 6682-7.
- Le Mercier, I. et al. (2014) Cancer Res 74, 1933-44.
- Lines, J.L. et al. (2014) Cancer Immunol Res 2, 510-7.
|54979 VISTA (D5L5T) XP® Rabbit mAb|
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