#39382 CYR61 (E5W3H) Rabbit mAb
|CYR61 (E5W3H) Rabbit mAb recognizes endogenous levels of total CYR61 protein. Based on amino acid sequence comparisons, this antibody is not predicted to cross-react with other CCN-family proteins.|
|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn103 of human CYR61 protein.|
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Western blot analysis of extracts from various cell lines using CYR61 (E5W3H) Rabbit mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).
Cysteine-rich protein 61 (CYR61, CCN1) is a secreted, matrix-associated protein belonging to the CCN family, a protein group characterized primarily by its high cysteine content (1). CYR61 regulates diverse cellular events including cell proliferation, differentiation, angiogenesis, and extracellular matrix formation. Research studies have implicated CYR61 in the development or progression of various cancers, including breast, prostate, lung, and hepatocellular carcinoma (1-4). Notably, its role in promoting cancer progression appears to be context-dependent. For example, investigators have shown that overexpression of CYR61 was positively associated with invasiveness of breast cancer cell lines (2), whereas in primary prostate tumors, expression levels were inversely correlated with tumor aggressiveness (3). In additional research studies of hepatocellular carcinoma, where CYR61 expression was positively associated with cancer progression, CYR61 was shown to be transcriptionally regulated by the Wnt/β-catenin signaling pathway (1).
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