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#4267 EGF Receptor (D38B1) XP® Rabbit mAb

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2019年3月25日15時35分 現在
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#4267S100 μL61,000
#4267L300 μL146,000
#4267T20 μL   for Custom Sampler Kit
Custom Antibody Sampler Kitの構成品を選択できます。

EGFR 製品一覧 | EGFR 抗体比較 | #4267 が入っているAntibody Sampler キット一覧

感度分子量 (kDa)抗体の由来貯法
内在性175 Rabbit IgG-20℃
種交差性 (社内試験済)
交差する可能性がある種 i


ヒト、マウス、サル -
4267 の推奨プロトコール i

最適な結果を得るために:Cell Signaling Technology (CST) 社は、各製品の推奨プロトコールを使用することを強くお薦めいたします。



ウェスタンブロッティング (1:1000)免疫沈降 (1:100)免疫組織染色 (パラフィン) (1:50)免疫蛍光細胞染色 (IF-IC) (1:50)フローサイトメトリー (1:50)


IHC-P: 抗体希釈液 / 抗原賦活化


内在性レベルのEGF Receptor タンパク質を検出します。他のErbB ファミリータンパク質とは交差しません。IHC-P およびIF-ICにおける種交差性はヒトのみとなります。
ヒトのEGF Receptor タンパク質の細胞質ドメインを含む融合タンパク質

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※下記の社内データは、すべて4267 の推奨プロトコールで実験した結果です。

Western Blotting

Western Blotting

Western blot analysis of extracts from A-431, BxPC3 and HeLa cells using EGF Receptor (D38B1) XP® Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded MDA-MB-468 (amplified EGFR, left), HT-29 (low EGFR, middle) and CAMA-1 (EGFR negative, right) cells using EGF Receptor (D38B1) XP® Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using EGF Receptor (D38B1) XP® Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human placenta using EGF Receptor (D38B1) XP® Rabbit mAb.

IHC-P (paraffin)

IHC-P (paraffin)

Immunohistochemical analysis of paraffin-embedded human lung carcinoma using EGF Receptor (D38B1) XP® Rabbit mAb.



Confocal immunofluorescent analysis of A549 cells, untreated (left) or treated with human epidermal growth factor (right), using EGF Receptor (D38B1) XP® Rabbit mAb (green). Blue pseudocolor = DRAQ5® #4084 (fluorescent DNA dye).

Flow Cytometry

Flow Cytometry

Flow cytometric analysis of Jurkat cells (red) and Kyse70 cells (blue), using EGF Receptor (D38B1) XP® Rabbit mAb.


The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation (1,2). Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins (3,4). c-Src is involved in phosphorylation of EGFR at Tyr845 (5). The SH2 domain of PLCγ binds at phospho-Tyr992, resulting in activation of PLCγ-mediated downstream signaling (6). Phosphorylation of EGFR at Tyr1045 creates a major docking site for the adaptor protein c-Cbl, leading to receptor ubiquitination and degradation following EGFR activation (7,8). The GRB2 adaptor protein binds activated EGFR at phospho-Tyr1068 (9). A pair of phosphorylated EGFR residues (Tyr1148 and Tyr1173) provide a docking site for the Shc scaffold protein, with both sites involved in MAP kinase signaling activation (2). Phosphorylation of EGFR at specific serine and threonine residues attenuates EGFR kinase activity. EGFR carboxy-terminal residues Ser1046 and Ser1047 are phosphorylated by CaM kinase II; mutation of either of these serines results in upregulated EGFR tyrosine autophosphorylation (10).

12630   SignalFire™ Plus ECL Reagent
12757   SignalFire™ Elite ECL Reagent
14343   Phospho-EGF Receptor (Thr678) Antibody
2085   EGF Receptor (E746-A750del Specific) (D6B6) XP® Rabbit mAb
2220   Phospho-EGF Receptor (Tyr1086) Antibody
2231   Phospho-EGF Receptor (Tyr845) Antibody
2232   EGF Receptor Antibody
2234   Phospho-EGF Receptor (Tyr1068) Antibody
2235   Phospho-EGF Receptor (Tyr992) Antibody
2236   Phospho-EGF Receptor (Tyr1068) (1H12) Mouse mAb
2237   Phospho-EGF Receptor (Tyr1045) Antibody
2238   Phospho-EGF Receptor (Ser1046/1047) Antibody
2239   EGF Receptor (1F4) Mouse mAb
2256   EGF Receptor (EGFR1) Mouse mAb (IP Specific)
2641   Phospho-EGF Receptor (Tyr998) (C24A5) Rabbit mAb
2646   EGF Receptor (C74B9) Rabbit mAb
2963   EGF Receptor (T43) Antibody
3056   Phospho-EGF Receptor (Thr669) Antibody
3197   EGF Receptor (L858R Mutant Specific) (43B2) Rabbit mAb
3265   EGF Receptor (V279) Antibody
3777   Phospho-EGF Receptor (Tyr1068) (D7A5) XP® Rabbit mAb
4404   Phospho-EGF Receptor (Tyr1148) Antibody
4405   EGF Receptor (15F8) Rabbit mAb
4407   Phospho-EGF Receptor (Tyr1173) (53A5) Rabbit mAb
64952   EGF Receptor vIII (D6T2Q) XP® Rabbit mAb
6883   SignalFire™ ECL Reagent
6963   Phospho-EGF Receptor (Tyr845) (D63B4) Rabbit mAb
7074   Anti-rabbit IgG, HRP-linked Antibody
7727   Biotinylated Protein Ladder Detection Pack
8059   SignalStain® DAB Substrate Kit
8102   SignalSlide® Phospho-EGF Receptor IHC Controls
8112   SignalStain® Antibody Diluent
8114   SignalStain® Boost IHC Detection Reagent (HRP, Rabbit)
8808   Phospho-EGF Receptor (Thr669) (D2F1) Rabbit mAb
9922   Phospho-EGF Receptor Antibody Sampler Kit

The manufacture, use, sale and import of this product is within the scope of one or more intellectual property rights (including patents and patent applications) owned or controlled by Cell Signaling Technology. The purchase of this product conveys to the buyer a non-transferrable right to use the purchased product only in research conducted by the buyer. The sale of the product is expressly conditioned on the buyer not using the products or its components (1) to analyze or reverse engineer the product for its chemical/physical properties and composition (including e.g., identification of the sequence); (2) in manufacturing; (3) to provide a service, information, or data to an unaffiliated third party for payment; (4) for therapeutic, diagnostic or prophylactic purposes; (5) resale, whether or not such product are resold for use in research; or for any other commercial purpose. For information on purchasing a license to this product for purposes other than research, contact Cell Signaling Technology, Inc. Business Development at busdev@cellsignal.com.
DRAQ5 is a registered trademark of Biostatus Limited.
XP is a registered trademark of Cell Signaling Technology, Inc.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.


EGF Receptor (D38B1) XP® Rabbit mAb

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