#47066 YKL-40 (E2L1M) Rabbit mAb
IHC-P: 抗体希釈液 / 抗原賦活化
|YKL-40 (E2L1M) Rabbit mAb recognizes endogenous levels of total YKL-40 protein.|
|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human YKL-40 protein.|
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Western blot analysis of extracts from THP-1 and A-204 using YKL-40 (E2L1M) Rabbit mAb upper) and loading control α-Actinin (D6F6) XP® Rabbit mAb #6487. As expected, A-204 is low to negative for YKL-40 expression.
Immunohistochemical analysis of paraffin-embedded human lung squamous cell carcinoma using YKL-40 (E2L1M) Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human non-Hodgkin's lymphoma using YKL-40 (E2L1M) Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded human serous papillary carcinoma of the ovary using YKL-40 (E2L1M) Rabbit mAb.
Immunohistochemical analysis of paraffin-embedded THP-1 cell pellet (left, positive) or A-204 cell pellet (right, negative) using YKL-40 (E2L1M) Rabbit mAb.
Confocal immunofluorescent analysis of THP-1 cells (left, positive) and A-204 cells (right, negative) using YKL-40 (E2L1M) Rabbit mAb (green). Actin filaments were labeled with DyLight™ 554 Phalloidin #13054 (red). Samples were mounted in ProLong® Gold Antifade Reagent with DAPI #8961 (blue).
YKL-40, also known as Chitinase-3-like protein 1 (CHI3L1), is a secreted glycoprotein encoded by the CHI3L1 gene (1,2). Unlike other members of the chitinase-like protein family, YKL-40 is not an active chitinase. It is produced by activated macrophages, chondrocytes, neutrophils, and synovial cells. It is a pro-inflammatory molecule that contributes to the progression of many inflammatory diseases, including fibrosis, neurodegenerative disease, breast, lung, prostate, liver, bladder, colon, and other types of cancers (3,4). Levels of YKL-40 in serum and plasma in patients with various types of tumors have been reported to predict poor prognosis, and in some clinical assays YKL-40 is being used as a predictive biomarker of cancer outcome (4).
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