#48868 IRF-3 (D9J5Q) Mouse mAb (Alexa Fluor® 647 Conjugate)
|IRF-3 (D9J5Q) Mouse mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total IRF-3 protein.|
|Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human IRF-3 protein.|
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Confocal immunofluorescent analysis of HT-29 cells, mock transfected (left) or transfected with Poly(dA:dT) (2 μg/mL, 6 hr; right), using IRF-3 (D9J5Q) Mouse mAb (Alexa Fluor® 647 Conjugate) (red). Actin filaments were labeled with DyLight™ 488 Phalloidin #12935 (green). Blue = DAPI #4083 (fluorescent DNA dye). Note the nuclear translocation of IRF-3 in a subset of cells (arrows).
Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).
|10949 IRF-3 (D9J5Q) Mouse mAb|
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