#50590 Granzyme B (D2H2F) Rabbit mAb (Alexa Fluor® 647 Conjugate)
|Granzyme B (D2H2F) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total Granzyme B protein.|
|Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human Granzyme B protein.|
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Flow cytometric analysis of human peripheral blood mononuclear cells, untreated (left column) or treated with anti-CD3 plus anti-CD28 (10 μg/ml, 72 hr; right column), using Granzyme B (D2H2F) Rabbit mAb (Alexa Fluor® 647 Conjugate) (top row) or concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Alexa Fluor® 647 Conjugate) #2985 (bottom row), and co-stained with a CD8 Antibody.
Granzymes are a family of serine proteases expressed by cytotoxic T lymphocytes and natural killer (NK) cells and are key components of immune responses to pathogens and transformed cells (1). Granzymes are synthesized as zymogens and are processed into mature enzymes by cleavage of a leader sequence. They are released by exocytosis in lysosome-like granules containing perforin, a membrane pore-forming protein. Granzyme B has the strongest apoptotic activity of all the granzymes as a result of its caspase-like ability to cleave substrates at aspartic acid residues thereby activating procaspases directly and cleaving downstream caspase substrates (2,3).
|17215 Granzyme B (D2H2F) Rabbit mAb|
The Alexa Fluor dye conjugates in this product are sold under license from Life Technologies Corporation, for research use only excluding use in combination with DNA microarrays and high content screening (HCS).
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