#71192 TAZ (E5P2N) Mouse mAb
|TAZ (E5P2N) Mouse mAb recognizes endogenous levels of total TAZ protein.|
|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro49 of human TAZ protein.|
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Western blot analysis of extracts from various cell lines using TAZ (E5P2N) Mouse mAb (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower). TAZ expression is undetectable in RL-7 extracts, as predicted from published gene expression databases.
Immunoprecipitation of TAZ from HeLa cell extracts. Lane 1 is 10% input, lane 2 is Mouse (E5Y6Q) mAb IgG2a Isotype Control #61656, and lane 3 is TAZ (E5P2N) Mouse mAb. Western blot analysis was performed using TAZ (D3I6D) Rabbit mAb #70148. Anti-rabbit IgG, HRP-linked Antibody #7074 was used as the secondary antibody.
TAZ is a transcriptional co-activator with a PDZ-binding motif that is regulated by its interaction with 14-3-3 proteins (1). TAZ shares homology with the WW domain of Yes-associated protein (YAP) (1). TAZ is proposed to modulate the switch between proliferation and differentiation of mesenchymal stem cells (MSC) via interaction with transcription factors Runx2 and PPARγ. This process is critical to normal tissue development and the prevention of tumor formation. Due to its role in determination of MSC fate, TAZ may have clinical relevance to several human diseases caused by an imbalance of MSC differentiation (2,3). TAZ is negatively regulated via phosphorylation by LATS1/2, core kinases in the Hippo signaling pathway that controls stem cell development, tissue growth and tumor development (4).
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