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#75885 SNX17 (E8F8Y) Rabbit mAb

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2019年3月22日15時35分 現在
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#75885S100 μL56,000
感度分子量 (kDa)抗体の由来貯法
内在性55Rabbit IgG-20℃
種交差性 (社内試験済)
交差する可能性がある種 i


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75885 の推奨プロトコール i

最適な結果を得るために:Cell Signaling Technology (CST) 社は、各製品の推奨プロトコールを使用することを強くお薦めいたします。



ウェスタンブロッティング (1:1000)


内在性レベルのSNX17 タンパク質を検出します。120 kDa 以上のサイズに、非特異的なバンドを検出する可能性があります。
ヒトのSNX17 タンパク質のAsn54 周辺領域 (合成ペプチド)

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※下記の社内データは、すべて75885 の推奨プロトコールで実験した結果です。

Western Blotting

Western Blotting

Western blot analysis of extracts from human prostate tissue and SK-MEL-5 and Malme-3M cells using SNX17 (E8F8Y) Rabbit mAb (upper) and β-Tubulin (D2N5G) Rabbit mAb #15115 (lower).


Sorting nexins are a family of cytoplasmic proteins characterized by the presence of a phosphatidylinositol 3-phosphate (PI3P) binding phox (PX) domain. This binding occurs mainly in the early endosome and allows for trafficking of the bound protein to either a degradative or recycling pathway (1).

Sorting nexin-17, or SNX17, has been shown to preferentially drive trafficking of integrins, receptors, and a variety of other proteins away from degradative pathways (1). In addition to PX domain interactions, SNX17 also binds the NPxY motif on the cytoplasmic tails of lipoprotein receptors via its FERM domain (protein 4.1, ezrin, radixin and moesin). Some of these proteins include the low density lipoprotein receptor-related protein 1 (LRP1) and apolipoprotein E receptor 2 (ApoER2) (3,4). LRP1 is known to bind APP, regulating its processing and causing an increase in Aβ production, a known risk factor for AD. By binding APP in addition to LRP1, SNX17 recycles both proteins to the plasma membrane, maintaining normal cell surface levels of each (3). SNX17 acts similarly with ApoER2, facilitating trafficking and increasing recycling to the plasma membrane. This assists in regulating the binding of ApoER2 and reelin, an interaction that is known to be important for neuronal migration and the formation of brain structures in early development, as well as synaptic function, learning, and memory in the adult brain (4). Through these and other interactions, SNX17 has been shown to have a potential role in a wide variety of neuronal pathways and diseases.

12630   SignalFire™ Plus ECL Reagent
12757   SignalFire™ Elite ECL Reagent
13953   Prestained Protein Marker, Broad Range (11-190 kDa)
6883   SignalFire™ ECL Reagent
7003   20X LumiGLO® Reagent and 20X Peroxide
7071   Phototope-HRP Western Blot Detection System, Anti-rabbit IgG, HRP-linked Antibody
7074   Anti-rabbit IgG, HRP-linked Antibody
7075   Anti-biotin, HRP-linked Antibody
7727   Biotinylated Protein Ladder Detection Pack
9997   Tris Buffered Saline with Tween® 20 (TBST-10X)
9999   Nonfat Dry Milk

Tween is a registered trademark of ICI Americas, Inc.
Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.


SNX17 (E8F8Y) Rabbit mAb

Metabolic Reprogramming in Disease