#96421 Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate)
|Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of IRF-3 protein only when phosphorylated at Ser386.|
|Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser386 of human IRF-3 protein.|
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Flow cytometric analysis of THP-1 cells differentiated with TPA #4174 (80 nM, 24 hr), and then mock transfected (blue) or transfected with poly(dA:dT) (5 ug/mL, 3 hr; green), using Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb (Alexa Fluor® 647 Conjugate) (solid lines) or concentration-matched Rabbit (DA1E) mAb IgG XP® Isotype Control (Alexa Fluor® 647 Conjugate) #2985 (dashed lines).
Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, IRF-9/ISGF3γ, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).
|37829 Phospho-IRF-3 (Ser386) (E7J8G) XP® Rabbit mAb|
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