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PTMScan® Directサービス
〜主要なシグナル伝達経路の活性を網羅的に調べる抗体アレイ〜

PTMScan Direct Services Overview

PTMScan® Direct技術は、特定のシグナル伝達経路の構成タンパク質に対する複数の抗体を使用した質量分析ベースの抗体アレイです。LC-MS/MSの前処理として、酵素消化したサンプルから目的のシグナル伝達経路の関連因子や興味あるキナーゼ基質のペプチドを濃縮します。一度のLC-MS/MS解析で、数百から数千の既知の標的タンパク質を定量することができます。

薬物処理や病態によるシグナル伝達経路の活性変化を一度に解析するため、6つのコンセプトに沿って選定されたPTM特異的抗体およびTotal抗体を使用します。各サービスで検出可能なターゲットの一例は下記タブを開いて表示されるリストでご確認ください。

解析受託サービスのワークフローやサンプル調製方法、納期については、こちらをご確認ください。

ご自身で抗体による濃縮とLC-MS/MS解析を実施される場合は、PTMScan®キットをご検討ください。

PTMScan® Direct Multi-Pathway

PTMScan® Direct Multi-Pathwayサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、Akt、MAPK、NF-κB、Jak/Stat経路を含む幅広いシグナル伝達経路の構成タンパク質とその関連タンパク質に狙いを絞ったスクリーニングと定量が可能になります。

紫でハイライトされたタンパク質はPTMScan® Direct Multi-Pathwayサービスによって測定可能な標的タンパク質を示しています。

Monitored phosphorylation in Adherens Junction Dynamics

Adherens Junction Dynamics

Monitored phosphorylation in AMPK Signaling

AMPK Signaling

Monitored phosphorylation in B Cell Receptor Signaling

B Cell Receptor Signaling

Monitored phosphorylation in Cell Cycle Control: G1/S Checkpoint

Cell Cycle Control: G1/S Checkpoint

Monitored phosphorylation in Cell Cycle Control: G2/M DNA Damage Checkpoint

Cell Cycle Control: G2/M DNA Damage Checkpoint

Monitored phosphorylation in ErbB / HER Signaling

ErbB / HER Signaling

Monitored phosphorylation in G Protein-coupled Receptors Signaling to MAPK / Erk

G Protein-coupled Receptors Signaling to MAPK / Erk

Monitored phosphorylation in Insulin Receptor Signaling

Insulin Receptor Signaling

Monitored phosphorylation in Jak / Stat Signaling: IL-6 Receptor Family

Jak / Stat Signaling: IL-6 Receptor Family

Monitored phosphorylation in Mitogen Activated Protein Kinase Signaling Cascades

Mitogen Activated Protein Kinase Signaling Cascades

Monitored phosphorylation in MAPK / Erk in Growth and Differentiation

MAPK / Erk in Growth and Differentiation

Monitored phosphorylation in NF-κB Signaling

NF-κB Signaling

Monitored phosphorylation in PI3 Kinase / Akt Signaling

PI3 Kinase / Akt Signaling

Monitored phosphorylation in Regulation of Actin Dynamics

Regulation of Actin Dynamics

Monitored phosphorylation in Regulation of Microtubule Dynamics

Regulation of Microtubule Dynamics

Monitored phosphorylation in SAPK / JNK Signaling Cascades

SAPK / JNK Signaling Cascades

Monitored phosphorylation in Signaling Pathways Activating p38 MAPK

Signaling Pathways Activating p38 MAPK

Monitored phosphorylation in T Cell Receptor Signaling

T Cell Receptor Signaling

Monitored phosphorylation in Toll-like Receptor Signaling

Toll-like Receptor Signaling

PTMScan Multi-Pathway Sample Report

PTMScan Multi-Pathway Sample Report

PTMScan Multi-Pathway Sample Report 4.7 MB

PTMScan® Direct Multi-Pathway Protein Sites
PTMScan® Direct Multi-Pathway Protein Sites 
4E-BP1 (Ser35)4E-BP1 (Ser44)4E-BP1 (Thr36)4E-BP1 (Thr37)
4E-BP1 (Thr41)4E-BP1 (Thr45)4E-BP1 (Thr46)4E-BP1 (Thr50)
4E-BP1 (Tyr34)4E-BP1 (Tyr54)4E-BP2 (Ser44)4E-BP2 (Thr36)
4E-BP2 (Thr37)4E-BP2 (Thr41)4E-BP2 (Thr45)4E-BP2 (Thr46)
4E-BP2 (Thr50)4E-BP2 (Tyr34)4E-BP2 (Tyr54)4E-BP3 (Thr23)
4E-BP3 (Thr32)53BP2 (Tyr610)A-Raf (Ser157)A-Raf (Ser299)
A-Raf (Tyr155)A-Raf (Tyr296)A-Raf (Tyr302)a-Tublin
Abi-2 (Ser216)Abi-2 (Tyr213)Abi-2 iso2 (Ser210)Abi-2 iso2 (Tyr207)
Abl (Ser113)Abl (Tyr115)Abl iso2 (Ser132)Abl iso2 (Tyr134)
Ack (Ser867)Ack (Tyr859)Ack (Tyr860)Ack iso3 (Ser945)
Ack iso3 (Tyr937)Ack iso3 (Tyr938)AFAP1L2 (Tyr54)AFAP1L2 (Tyr56)
AKNA (Ser997)Akt1 (Ser473)Akt1 (Thr305)Akt1 (Thr308)
Akt1 (Thr312)Akt1 (Thr479)Akt1 (Tyr474)Akt2
Akt2 (Ser474)Akt2 (Ser476)Akt2 (Ser478)Akt2 (Thr306)
Akt2 (Thr309)Akt2 (Thr313)Akt2 (Tyr122)Akt2 (Tyr316)
Akt2 (Tyr475)Akt3 (Ser472)Akt3 (Ser474)Akt3 (Ser476)
Akt3 (Thr302)Akt3 (Thr305)Akt3 (Tyr473)ANP-β (Thr540)
ANP-β iso2 (Thr540)Arg (Ser159)Arg (Tyr161)Arg iso4 (Ser123)
Arg iso4 (Tyr125)Arg iso6 (Ser138)Arg iso6 (Tyr140)ARHGEF17 (Ser383)
ATF-2 (Thr69)ATF-2 (Thr71)ATF-7ATF-7 (Ser424)
ATF-7 (Ser428)ATF-7 (Ser429)ATF-7 (Ser434)ATF-7 (Thr418)
ATF-7 (Thr432)ATF-7 (Tyr421)ATF-7 iso2 (Ser392)ATF-7 iso2 (Ser396)
ATF-7 iso2 (Ser397)ATF-7 iso2 (Ser402)ATF-7 iso2 (Thr386)ATF-7 iso2 (Thr400)
ATF-7 iso2 (Tyr389)ATG2A (Tyr1314)ATM (Ser1981)ATM (Ser1988)
Aurora A (Thr287)Aurora A (Thr288)Aurora A (Thr292)Aurora B (Thr232)
Aurora B (Thr236)Aurora C (Thr198)Aurora C (Thr202)Aurora C iso2 (Thr164)
Aurora C iso2 (Thr168)Axl (Tyr702)Axl (Tyr703)b-Actin
B-Raf (Ser446)B-Raf (Ser447)B-Raf (Thr440)Bad (Ser71)
Bad (Ser74)Bad (Ser75)Bad (Ser91)Bad (Thr80)
Bad (Tyr76)BAG3BAG3 (Tyr86)BAG3 (Tyr93)
Bcr/Abl (Ser773)Bcr/Abl (Tyr775)Bcr/Abl iso2 (Ser627)Bcr/Abl iso2 (Tyr629)
BLM (Ser74)BMPR2 (Ser547)BMPR2 (Ser548)BMPR2 (Ser549)
BMPR2 (Tyr546)BMPR2 (Tyr551)Caspase-3 (Asp175)Caspase-3 (Ser176)
Caveolin-1 (Thr15)Caveolin-1 (Tyr14)Caveolin-1 (Tyr25)Caveolin-1 (Tyr6)
CBP (Ser1578)CCNB1CD28 (Tyr191)CD2AP (Ser542)
CD2AP (Ser546)CD2AP (Ser550)CD2AP (Ser553)CD2AP (Ser554)
CD2AP (Thr539)CD2AP (Thr551)CD2AP (Tyr541)CD2AP (Tyr548)
CD45 (Tyr705)Cdc25C (Ser168)Cdc25C iso3 (Ser125)CDK1
CDK1 (Thr14)CDK1 (Tyr15)CDK1 (Tyr19)CDK2
CDK2 (Thr14)CDK2 (Tyr15)CDK3CDK3 (Thr14)
CDK3 (Tyr15)CDK5 (Tyr15)CdkL5 (Ser446)CdkL5 (Ser465)
CdkL5 (Ser468)CdkL5 (Tyr171)CdkL5 (Tyr614)CELSR2 (Tyr2679)
CENTD2 (Tyr431)CENTD2 iso1 (Tyr191)CHERP (Ser902)CHERP (Ser904)
Chk1 (Ser343)Chk1 (Ser345)Chk1 (Ser357)Chk1 (Thr362)
CK1-G2 (Ser32)CK1-G3 (Ser31)CK1-G3 iso3 (Ser31)Claudin-4 (Tyr208)
Cortactin (Tyr334)Cortactin iso3 (Tyr297)CRIP2 (Ser74)CRIP2 (Tyr75)
CRIP2 (Tyr77)CTNNA1CTNNA2CTNNB1
CTNNB1 (Ser552)CTNNB1 (Ser675)CTNNB1 (Ser680)CTNNB1 (Ser681)
CTNNB1 (Thr551)CTNNB1 (Thr556)CTNNB1 (Thr679)CTTN
DBNDD1 (Ser119)DBNDD1 (Ser121)DBNDD1 (Thr123)DBNL (Tyr162)
DBNL iso2 (Tyr162)DBNL iso3 (Tyr162)DDR1 (Tyr792)DDR1 (Tyr796)
DDR1 (Tyr797)DDX29 (Tyr808)DDX29 (Tyr811)Deptor (Ser279)
Deptor (Ser280)Deptor (Ser282)Deptor (Ser283)Deptor (Ser291)
Deptor (Ser292)Deptor (Ser293)Deptor (Ser299)Deptor (Thr295)
Desmoglein 2 (Ser1059)Desmoglein 2 (Ser1060)Desmoglein 2 (Ser1068)Desmoglein 2 (Thr1056)
Desmoglein 2 (Tyr1061)Desmoglein 2 (Tyr940)Desmoplakin 3 (Ser36)Desmoplakin 3 (Ser39)
Desmoplakin 3 (Ser665)Desmoplakin 3 (Thr21)Desmoplakin 3 (Tyr20)Desmoplakin 3 (Tyr22)
Diaphanous 1 (Tyr128)Diaphanous 1 iso2 (Tyr119)DNA-PK (Ser893)DOT1L (Ser741)
DOT1L (Ser753)DOT1L (Thr735)DOT1L (Thr751)DOT1L (Tyr738)
DYNLL1DYNLL2DYRK1A (Tyr321)DYRK1A iso2 (Tyr312)
DYRK1A iso4 (Tyr321)DYRK1B (Tyr273)DYRK1B iso2 (Tyr273)eEF1A1 (Tyr177)
eEF1AL3 (Tyr177)EGFR (Tyr869)EIF1AXeIF1AX (Ser74)
eIF1AX (Thr73)EIF1AYeIF1AY (Ser74)eIF1AY (Thr73)
EIF2AEIF2S1EIF4EBP2EIF4H
EphB4 (Tyr574)EphB4 (Tyr581)ERC1 (Ser897)ERC1 iso4 (Ser829)
Erk1Erk1 (Thr202)Erk1 (Tyr204)Erk2
Erk2 (Thr185)Erk2 (Tyr187)Erk3Erk5 (Thr219)
Erk5 (Tyr221)FAK (Ser574)FAK (Thr575)FAK (Tyr194)
FAK (Tyr570)FAK (Tyr576)FAK (Tyr577)FAK iso2 (Ser422)
FAK iso2 (Thr423)FAK iso2 (Tyr13)FAK iso2 (Tyr418)FAK iso2 (Tyr424)
FAK iso2 (Tyr425)FAK iso5 (Ser574)FAK iso5 (Thr575)FAK iso5 (Tyr194)
FAK iso5 (Tyr570)FAK iso5 (Tyr576)FAK iso5 (Tyr577)FGFR1 (Tyr583)
FGFR1 (Tyr585)FGFR1 (Tyr653)FGFR1 (Tyr654)FGFR4 (Tyr642)
FGFR4 (Tyr643)FGFR4 iso3 (Tyr874)FGFR4 iso3 (Tyr875)FLVCR1 (Tyr22)
FOXK1 (Thr273)Fyn (Tyr420)Fyn iso2 (Tyr417)G-α-s (Tyr190)
G-α-s iso2 (Tyr176)G-α-s iso3 (Tyr175)G-α-s iso4 (Tyr833)G-α-s iso5 (Tyr819)
Gab2 (Ser474)Gab2 (Ser480)Gab2 (Ser488)Gab2 (Tyr476)
GADS (Tyr45)GAPDHGIT1 (Ser508)GIT1 (Tyr510)
GIT1 iso3 (Ser521)GIT1 iso3 (Tyr523)GRB2GSK-3α (Ser20)
GSK-3α (Ser21)GSK-3α (Ser278)GSK-3α (Ser39)GSK-3α (Ser41)
GSK-3α (Thr19)GSK-3α (Tyr279)GSK-3β (Ser215)GSK-3β (Tyr216)
GSK-3β iso2 (Ser215)GSK-3β iso2 (Tyr216)H3Hck (Ser520)
Hck (Tyr411)Hck (Tyr51)Hck (Tyr522)HER3 (Tyr1054)
HIPK1 (Ser355)HIPK1 (Tyr352)HIPK2 (Ser364)HIPK2 (Tyr361)
HIPK3 (Tyr359)hnRNP C1/C2 (Ser121)hnRNP C1/C2 iso2 (Ser100)hnRNP C1/C2 iso2 (Ser107)
hnRNP C1/C2 iso2 (Ser108)hnRNP C1/C2 iso2 (Tyr105)hnRNP C1/C2 iso4 (Ser100)hnRNP C1/C2 iso4 (Ser107)
hnRNP C1/C2 iso4 (Ser108)hnRNP C1/C2 iso4 (Tyr105)HNRPLL (Ser61)Hrs (Ser240)
Hrs (Thr239)Hrs (Thr287)Hrs (Tyr286)HSP90AA1
HSP90AB1HSPB1HUS1B (Ser121)ICK (Thr162)
ICK (Tyr159)IGF1R (Tyr1161)IGF1R (Tyr1165)IGF1R (Tyr1166)
IkBα (Ser36)IkBε (Ser157)IkBε iso3 (Ser80)IKKγ (Ser376)
IKKγ (Ser377)IKKγ (Ser383)IKKγ (Tyr374)InsR (Tyr1185)
InsR (Tyr1189)InsR (Tyr1190)InsR iso2 (Tyr1173)InsR iso2 (Tyr1177)
InsR iso2 (Tyr1178)IRS1IRS-1 (Ser463)IRS-1 (Tyr465)
IRS-2 (Thr544)IRS-2 (Tyr540)IRS-2 (Tyr542)ITK (Tyr220)
JNK1 (Thr183)JNK1 (Tyr185)JNK1 iso2 (Thr183)JNK1 iso2 (Tyr185)
JNK2 (Thr183)JNK2 (Thr188)JNK2 (Tyr185)JNK2 iso2 (Thr183)
JNK2 iso2 (Thr188)JNK2 iso2 (Tyr185)JNK2 iso3 (Thr183)JNK2 iso3 (Thr188)
JNK2 iso3 (Tyr185)JNK3 (Thr221)JNK3 (Tyr223)JNK3 iso2 (Thr221)
JNK3 iso2 (Tyr223)Jun (Ser73)JunD (Ser100)JunD (Ser90)
KIRREL (Tyr622)KIRREL (Tyr625)KTN1 (Ser242)KTN1 (Ser243)
KTN1 (Thr231)KTN1 (Thr232)KTN1 (Tyr233)Lamin A/C (Ser404)
Lamin A/C (Ser407)Lamin A/C iso2 (Ser404)Lamin A/C iso2 (Ser407)LARP (Ser293)
LARP (Ser627)LARP (Ser631)LARP (Thr303)LARP (Tyr296)
LARP (Tyr633)LARP iso3 (Ser216)LARP iso3 (Ser550)LARP iso3 (Ser554)
LARP iso3 (Thr226)LARP iso3 (Tyr219)LARP iso3 (Tyr556)LARP iso4 (Ser293)
LARP iso4 (Ser627)LARP iso4 (Ser631)LARP iso4 (Thr303)LARP iso4 (Tyr296)
LARP iso4 (Tyr633)Latrophilin 2 (Tyr1372)Latrophilin 2 (Tyr1406)Latrophilin 2 (Tyr1407)
Latrophilin 2 iso2 (Tyr1316)Latrophilin 2 iso2 (Tyr1350)Latrophilin 2 iso2 (Tyr1351)LBR (Ser159)
LBR (Ser167)LBR (Tyr161)LBR (Tyr166)LBR (Tyr22)
Lck (Tyr394)LEMD2 (Ser499)LEMD2 (Ser501)LISCH (Ser321)
LISCH (Ser326)LISCH (Ser332)LISCH (Thr327)LISCH (Tyr323)
LISCH (Tyr328)LISCH (Tyr372)LMO7 (Ser318)LMO7 (Ser322)
LMO7 (Tyr323)LMO7 iso2 (Ser318)LMO7 iso2 (Ser322)LMO7 iso2 (Tyr323)
LMO7 iso3 (Ser318)LMO7 iso3 (Ser322)LMO7 iso3 (Tyr323)LPP (Tyr273)
LPP (Tyr275)LRP6 (Ser1490)LRP6 (Thr1479)LRP6 (Thr1493)
LRP6 (Tyr1480)LRRK1 (Ser360)LRRK1 (Thr358)Lyn (Tyr397)
Lyn iso2 (Tyr376)Lyric (Tyr364)Lyric iso3 (Tyr364)MAP1B (Ser1171)
MAP1B (Ser1322)MAP1B (Ser1324)MAP1B (Ser1326)MAP1B (Ser1330)
MAP1B (Ser1339)MAP1B (Ser1396)MAP1B (Ser1400)MAP1B (Ser1406)
MAP1B (Ser1412)MAP1B (Ser1443)MAP1B (Ser1869)MAP1B (Ser1899)
MAP1B (Ser1915)MAP1B (Ser1917)MAP1B (Ser1922)MAP1B (Ser1939)
MAP1B (Ser1956)MAP1B (Ser1973)MAP1B (Ser2007)MAP1B (Ser2024)
MAP1B (Thr1334)MAP1B (Thr1864)MAP1B (Thr1898)MAP1B (Thr1925)
MAP1B (Thr1964)MAP1B (Thr2010)MAP1B (Thr2011)MAP1B (Thr2034)
MAP1B (Tyr1170)MAP1B (Tyr1174)MAP1B (Tyr1336)MAP1B (Tyr1337)
MAP1B (Tyr1410)MAP1B (Tyr1454)MAP1B (Tyr1870)MAP1B (Tyr1872)
MAP1B (Tyr1904)MAP1B (Tyr1905)MAP1B (Tyr1906)MAP1B (Tyr1921)
MAP1B (Tyr1923)MAP1B (Tyr1938)MAP1B (Tyr1940)MAP1B (Tyr1955)
MAP1B (Tyr1972)MAP1B (Tyr1974)MAP1B (Tyr2006)MAP1B (Tyr2023)
MAP1B (Tyr2040)MAP1B (Tyr2042)MAP1B (Tyr2057)MAP1B (Tyr2059)
MAP4 (Tyr47)MAP4 iso5 (Tyr47)MAP4 iso9 (Tyr47)MCM2 (Ser139)
MCM2 (Tyr137)MEK1 (Ser218)MEK1 (Ser222)MEK2 (Ser222)
MEK2 (Ser226)MEKK2 (Ser164)MEKK2 (Tyr169)Mer (Tyr749)
Mer (Tyr753)Mer (Tyr754)Met (Ser1236)Met (Tyr1234)
Met (Tyr1235)MINK (Tyr505)MINK (Tyr507)MINK iso4 (Tyr505)
MINK iso4 (Tyr507)MKK3 (Ser253)MKP-1 (Ser359)MKP-1 (Ser364)
MKP-1 (Ser366)MLF1 (Ser34)MLK4 (Tyr1028)MRCKa (Ser1545)
MRCKa (Tyr1544)MRCKa iso2 (Ser1567)MRCKa iso2 (Tyr1566)MRCKa iso3 (Ser1451)
MRCKa iso3 (Tyr1450)MSK1 (Ser376)MSK1 (Ser381)MSK1 (Tyr375)
MSK2 (Ser360)MSK2 (Ser365)MSK2 (Tyr359)MSK2 iso2 (Ser360)
MSK2 iso2 (Ser365)MSK2 iso2 (Tyr359)MST3 (Thr182)MST3 (Thr184)
MST3 (Thr190)MST3 (Thr194)MST3 iso2 (Thr170)MST3 iso2 (Thr172)
MST3 iso2 (Thr178)MST3 iso2 (Thr182)MTHFD1mTOR (Ser2442)
mTOR (Ser2448)mTOR (Ser2450)mTOR (Ser2454)mTOR (Thr2444)
mTOR (Thr2446)mTOR (Tyr2449)MUC1 (Tyr1218)MUC1 (Tyr1229)
MUC1 iso2 (Tyr227)MUC1 iso2 (Tyr238)MUC1 iso6 (Tyr193)MUC1 iso6 (Tyr204)
MYCMYO1E (Ser980)MYO1E (Ser983)MYO1E (Tyr7)
MYO1E (Tyr9)MYO1E (Tyr971)MYO1E (Tyr974)MYPT1 (Ser888)
MYPT1 (Ser903)MYPT1 (Thr892)MYPT1 (Tyr890)MYPT1 (Tyr911)
MYPT1 (Tyr913)MYST4 (Ser1048)MYST4 iso4 (Ser1048)NF-κB p105 (Ser944)
NF-κB p105 (Thr943)NF-κB p105 (Thr950)Notch1Notch1 (Ser2136)
NuMA-1 (Tyr1774)Numb (Tyr15)Numb iso2 (Tyr15)Numb iso3 (Tyr15)
NumbL (Tyr56)OSR1 (Ser263)OSR1 (Thr185)OSR1 (Thr189)
P130 Cas (Thr385)P130 Cas (Tyr115)P130 Cas (Tyr128)p38α (Thr180)
p38α (Tyr182)p38α iso2 (Thr180)p38α iso2 (Tyr182)p38δ (Thr180)
p38δ (Tyr182)p38γ (Thr183)p38γa (Tyr185)p53 (Ser392)
p70 S6K (Ser243)p70 S6K (Thr248)p70 S6K (Thr250)p70 S6K (Thr252)
p70 S6K (Thr256)p70 S6K iso2 (Ser220)p70 S6K iso2 (Thr225)p70 S6K iso2 (Thr227)
p70 S6K iso2 (Thr229)p70 S6K iso2 (Thr233)p70 S6Kb (Ser219)p70 S6Kb (Thr226)
p70 S6Kb (Thr228)p90RSKp90RSK (Ser221)p90RSK (Thr225)
p90RSK (Thr573)p90RSK (Tyr220)p90RSK (Tyr228)p90RSK (Tyr576)
p90RSK iso3 (Ser230)p90RSK iso3 (Thr234)p90RSK iso3 (Thr582)p90RSK iso3 (Tyr229)
p90RSK iso3 (Tyr237)p90RSK iso3 (Tyr585)PAK1IP1 (Ser365)PAK6 (Ser132)
PAR-4 (Ser211)PAR-4 (Ser212)PAR-4 (Tyr213)PARD3 (Tyr388)
PARD3 iso10 (Tyr388)PARD3 iso5 (Tyr344)PARP1PCMT1 (Tyr213)
PCTAIRE1 (Tyr176)PCTAIRE1 iso3 (Tyr250)PCTAIRE2 (Tyr203)PDGF Receptor α
PDGF Receptor α (Ser566)PDGF Receptor α (Ser755)PDGF Receptor α (Ser847)PDGF Receptor α (Tyr1018)
PDGF Receptor α (Tyr572)PDGF Receptor α (Tyr574)PDGF Receptor α (Tyr742)PDGF Receptor α (Tyr754)
PDGF Receptor α (Tyr849)PDK1 (Ser241)PDK1 (Thr245)PDK1 iso4 (Ser114)
PDK1 iso4 (Thr118)PHC3 (Ser616)PHC3 (Thr609)PHC3 (Thr614)
PHC3 (Thr621)PHKA1 (Ser729)PHKA1 (Ser735)PHKA1 (Tyr75)
PHKB (Tyr29)PHKB iso2 (Tyr22)PHKB iso3 (Tyr29)PIK3C2A (Ser409)
PIK3CA (Ser507)PIK3CA (Tyr644)PIK3CB (Tyr425)PIK3R1
PIK3R1 (Tyr467)PIK3R2PIK3R2 (Tyr464)PIK3R3
PIK3R3 (Tyr199)PIP5K (Tyr1772)PITSLRE (Tyr449)PITSLRE B (Tyr437)
PITSLRE B iso10 (Tyr93)PITSLRE iso12 (Tyr93)PKAR2A (Tyr385)PKCα
PKCα (Thr48)PKCβPKCβ (Thr48)PKCβ (Thr500)
PKCβ (Thr504)PKCβ iso2 (Thr48)PKCβ iso2 (Thr500)PKCβ iso2 (Thr504)
PKCδ (Ser645)PKCδ (Ser647)PKCδ (Ser654)PKCδ (Ser664)
PKCδ (Tyr646)PKCδ iso13 (Ser645)PKCδ iso13 (Ser647)PKCδ iso13 (Ser654)
PKCδ iso13 (Ser664)PKCδ iso13 (Tyr646)PKCQPKD2 (Ser375)
PKD2 (Tyr378)PKN1 (Ser916)PKN2 (Ser306)PLCγ1 (Ser1248)
PLCγ1 (Ser470)PLCγ1 (Thr50)PLCγ1 (Tyr472)PLCγ1 iso2 (Ser1249)
PLCγ1 iso2 (Ser470)PLCγ1 iso2 (Thr50)PLCγ1 iso2 (Tyr472)PLEKHA2 (Ser182)
PLEKHA2 (Ser184)PLEKHA2 (Tyr185)PLEKHA5 (Tyr590)PLEKHG4 (Ser677)
PLEKHG4 (Tyr676)PPP1CBPPP1CB (Tyr304)PPP1CB (Tyr306)
PPP2R5D (Tyr451)PRAS40 (Thr246)PRAS40 iso3 (Thr266)PRC1 (Ser513)
PRC1 (Tyr511)PRC1 iso2 (Ser483)PRC1 iso2 (Tyr481)PRC1 iso3 (Ser472)
PRC1 iso3 (Tyr470)PRP4 (Tyr849)PSMC4PTP-PEST (Tyr88)
PTPN13 (Tyr943)PTPN13 iso3 (Tyr943)PTPRA (Tyr295)PTPRA (Tyr798)
PTPRA iso2 (Tyr286)PTPRA iso2 (Tyr789)PTPRD (Tyr1699)PTPRD iso5 (Tyr1292)
PTPRD iso7 (Tyr1283)PTPRE (Tyr696)PTPRE iso2 (Tyr638)PTPRG (Tyr906)
PTPRG (Tyr911)PTPRJ (Thr339)PTPRK (Tyr940)PTPRM (Tyr953)
PTPRS (Tyr1735)Pyk2 (Tyr579)Pyk2 (Tyr580)Pyk2 iso2 (Tyr579)
Pyk2 iso2 (Tyr580)RAB23 (Ser186)RAB23 (Ser187)RAB23 (Ser188)
RAB23 (Thr184)Rab7 (Tyr183)RABEP1 (Tyr501)RABEP1 iso2 (Tyr501)
Raf1 (Ser338)Raf1 (Ser339)Raf1 (Tyr340)Raf1 (Tyr341)
RAIG1 (Ser321)RAIG1 (Ser345)RAIG1 (Thr322)RAIG1 (Tyr317)
RAIG1 (Tyr347)RAIG1 (Tyr350)Rap1GAP (Thr23)Rap1GAP (Tyr27)
Rap1GAP iso2 (Thr23)Rap1GAP iso2 (Tyr27)Rap1GAP iso3 (Thr54)Rap1GAP iso3 (Tyr58)
Rap1GAP iso5 (Thr87)Rap1GAP iso5 (Tyr91)RAPGEF2 (Ser960)RAPGEF2 iso2 (Ser948)
RAPH1 (Ser822)RAPH1 (Thr830)RAPH1 (Tyr524)RAPH1 (Tyr823)
Rb (Ser773)Rb (Ser780)Rb (Ser788)Rb (Ser794)
Rb (Ser795)Rb (Thr774)Rb (Thr778)Rb (Tyr771)
Rb (Tyr790)RBBP6 (Ser516)RbBP6 iso2 (Ser516)RBM14
RBM14 (Ser215)RBM14 (Ser220)RBM14 (Ser225)RBM14 (Tyr226)
RBM34 (Tyr71)RBM47 (Ser540)RBM47 (Thr533)RBM47 (Thr554)
RBM47 (Tyr537)RBM47 (Tyr541)RBMS2 (Ser277)RBMS2 (Ser280)
RBMS2 (Ser285)RBMS2 (Tyr290)RhoA (Tyr34)RhoA iso3 (Tyr34)
RhoG (Tyr32)RICS (Tyr2048)Rictor (Ser1320)Rictor (Tyr1269)
Rin1 (Thr696)Rin1 (Tyr36)Rin1 (Tyr698)Rin1 (Tyr701)
RIPK1RIPK2 (Ser176)RPS3ARSK2
RSK2 (Ser227)RSK2 (Thr231)RSK2 (Thr577)RSK2 (Tyr226)
RSK2 (Tyr234)RSK2 (Tyr580)RSK3RSK4
RSK4 (Ser232)RSK4 (Thr236)RSK4 (Tyr231)RSK4 (Tyr239)
S6 (Ser235)S6 (Ser236)S6 (Ser240)S6 (Ser242)
S6 (Ser244)S6 (Ser246)S6 (Ser247)S6 (Thr241)
SBNO1 (Ser815)SBNO1 (Ser817)SBNO1 (Ser818)SBNO1 (Ser823)
SBNO1 (Ser837)SBNO1 (Thr819)SBNO1 (Thr835)SEC6L1 (Tyr737)
SF3A1 (Ser413)SF3A1 (Ser423)SF3A1 (Thr416)SgK223 (Ser490)
Shb (Tyr268)Shb (Tyr272)SHIP-2 (Tyr886)SHP-1 (Tyr301)
SHP-1 iso5 (Tyr301)SHP-2 (Ser302)SHP-2 (Tyr304)SIPA1L1 (Ser1632)
SIPA1L1 (Tyr1633)SLITRK4 (Tyr811)SLITRK5 (Tyr749)SLITRK5 (Tyr751)
SLK (Tyr1225)SMAD1Smad1 (Ser462)Smad1 (Ser463)
Smad1 (Ser465)Smad2Smad3Smad5
Smad5 (Ser463)Smad5 (Ser465)Smad8 (Ser464)Smad8 (Ser465)
Smad8 (Ser467)Smad9SMG1 (Ser147)SOS2 (Ser1132)
Src (Tyr419)STAM2 (Ser372)STAM2 (Ser375)STAM2 (Tyr371)
STAM2 (Tyr374)Stat1Stat3Stat3 (Ser691)
Stat3 (Ser701)Stat3 (Thr708)Stat3 (Tyr705)Stat3 iso3 (Ser691)
Stat3 iso3 (Ser701)Stat3 iso3 (Thr708)Stat3 iso3 (Tyr705)Stat5A (Tyr694)
Stat5B (Tyr699)Stat6 (Tyr641)STLK3 (Ser309)STLK3 (Thr231)
STLK3 (Thr235)Syk (Tyr525)Syk (Tyr526)TANC2 (Tyr1919)
TANC2 (Tyr1920)TBC1D1 (Ser237)Tec (Tyr228)Tec (Tyr233)
Tensin 1 (Tyr766)TIE1 (Ser472)Timeless (Ser1149)TMOD3 (Tyr86)
TMPO (Ser388)TMPO (Tyr390)TMPO (Tyr394)TMPO iso2 (Ser279)
TMPO iso2 (Tyr281)TMPO iso2 (Tyr285)TPD52L2TPD52L2 (Ser96)
TPD52L2 (Tyr106)TPX2 (Ser322)TPX2 (Thr323)TPX2 (Thr338)
TPX2 (Tyr324)TSG118 (Tyr255)TSSC4 (Ser143)TSSC4 (Ser146)
TSSC4 (Tyr155)Tyro3 (Tyr681)Tyro3 (Tyr685)Tyro3 (Tyr686)
ULK4 (Thr134)WDR32 (Ser61)WDR32 (Ser63)WNK1 (Thr1963)
WNK1 iso4 (Thr2215)YAP1 (Tyr407)YAP1 iso2 (Tyr391)Yes (Tyr426)
YSK1 (Thr166)YSK1 (Thr168)YSK1 (Thr174)YSK1 (Thr178)
ZAP3 (Ser561)ZAP3 iso4 (Ser756)ZAP-70 (Ser289)ZAP-70 (Ser301)
ZAP-70 (Ser313)ZAP-70 (Ser317)ZAP-70 (Ser320)ZAP-70 (Thr494)
ZAP-70 (Tyr292)ZAP-70 (Tyr315)ZAP-70 (Tyr319)ZAP-70 (Tyr492)
ZAP-70 (Tyr493)ZC3H15 (Ser135)ZC3H15 (Tyr137)ZNF598 (Ser288)
ZNF598 iso2 (Ser288)ZNF828 (Ser405)ZNF828 (Thr403)ZO-1 (Ser1360)
ZO-1 (Tyr1354)ZO-1 (Tyr1355)ZO-1 (Tyr1361)ZO-1 iso2 (Ser1280)
ZO-1 iso2 (Tyr1274)ZO-1 iso2 (Tyr1275)ZO-1 iso2 (Tyr1281)Zyxin (Ser169)
Zyxin (Ser170)Zyxin (Tyr172)  

* The following targets are included as control markers for total protein: β-Actin, Histone H3, GAPDH, and α-Tubulin.

PTMScan® Direct PI3K / Akt Signaling

PTMScan® Direct PI3K/Aktサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、PI3K/Akt経路の構成タンパク質とその関連タンパク質に狙いを絞ったスクリーニングと定量が可能になります。

PTMScan Direct PI3K/Akt Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

PI3K / Akt Protein Sites
PI3K / Akt Protein Sites
4E-BP1 (Ser35)4E-BP1 (Ser44)4E-BP1 (Thr36)4E-BP1 (Thr37)
4E-BP1 (Thr41)4E-BP1 (Thr45)4E-BP1 (Thr46)4E-BP1 (Thr50)
4E-BP1 (Tyr34)4E-BP1 (Tyr54)4E-BP2 (Ser44)4E-BP2 (Thr36)
4E-BP2 (Thr37)4E-BP2 (Thr41)4E-BP2 (Thr45)4E-BP2 (Thr46)
4E-BP2 (Thr50)4E-BP2 (Tyr34)4E-BP2 (Tyr54)4E-BP3 (Thr23)
4E-BP3 (Thr27)4E-BP3 (Thr31)4E-BP3 (Thr32)ACTB (Thr201)
ACTG1 (Thr201)Akt1 (Ser473)Akt1 (Thr305)Akt1 (Thr308)
Akt1 (Thr312)Akt1 (Tyr315)Akt2 (Ser474)Akt2 (Ser476)
Akt2 (Ser478)Akt2 (Thr309)Akt2 (Thr313)Akt2 (Tyr316)
Akt2 (Tyr475)Akt3 (Ser472)Akt3 (Ser474)Akt3 (Ser476)
Akt3 (Thr298)Akt3 (Thr305)Akt3 (Tyr473)ATR (Ser435)
ATR (Ser436)BAD (Ser71)BAD (Ser74)BAD (Ser75)
BAD (Ser91)BAD (Ser97)BAD (Ser99)BAD (Thr80)
BAD (Tyr76)CTNND1 iso3 (Ser168)CTNND1 iso3 (Thr147)CTNND1 iso3 (Thr149)
CTNND1 iso3 (Thr152)CTNND1 iso4 (Ser168)CTNND1 iso4 (Thr147)CTNND1 iso4 (Thr149)
CTNND1 iso4 (Thr152)CTNND1 (Ser168)CTNND1 (Thr147)CTNND1 (Thr149)
CTNND1 (Thr152)DNMT1 iso2 (Ser748)DNMT1 (Ser732)Dok1 (Tyr341)
Dok2 (Tyr299)eIF4H (Ser230)eIF4H (Thr217)eIF4H (Thr220)
EphA2 (Thr593)EphA2 (Thr771)EphA2 (Thr773)EphA2 (Thr774)
EphA2 (Tyr588)EphA2 (Tyr772)FAK iso2 (Ser211)FAK iso2 (Ser422)
FAK iso2 (Thr227)FAK iso2 (Tyr216)FAK iso2 (Tyr424)FAK iso2 (Tyr425)
FAK (Ser392)FAK (Ser574)FAK (Thr408)FAK (Tyr397)
FAK (Tyr576)FAK (Tyr577)FOXK1 (Thr273)FOXO1A (Ser256)
FOXO3A (Ser43)FOXO3A (Ser48)FOXO3A (Ser55)FOXO3A (Thr51)
Fyn iso2 (Tyr417)Fyn (Tyr420)GAPDH (Thr153)GOLGA3 (Ser1430)
GOLGA3 (Ser983)GOLGA4 (Ser40)GOLGA4 (Ser41)GOLGA4 (Thr39)
GOLGA4 (Thr43)GSK3A (Ser20)GSK3A (Ser21)GSK3A (Ser39)
GSK3A (Ser41)GSK3A (Thr19)GSK3A (Thr46)HGK iso5 (Ser908)
HGK iso5 (Thr187)HGK iso5 (Thr910)HGK iso7 (Ser463)HGK iso7 (Ser934)
HGK iso7 (Thr127)HGK iso7 (Thr936)HGK (Ser523)HGK (Ser913)
HGK (Thr187)HGK (Thr915)HRas (Tyr32)HRas (Tyr64)
IRS1 (Ser303)IRS1 (Ser307)IRS1 (Ser312)IRS1 (Ser315)
IRS1 (Ser323)IRS1 (Ser603)IRS1 (Ser604)IRS1 (Ser616)
IRS1 (Thr305)IRS1 (Thr309)IRS1 (Thr311)IRS1 (Thr608)
IRS1 (Tyr1179)IRS1 (Tyr612)IRS2 (Ser594)IRS2 (Tyr598)
KHSRP (Ser132)KRas iso2 (Tyr32)KRas iso2 (Tyr64)KRas (Tyr32)
KRas (Tyr64)lamin A/C iso2 (Ser404)lamin A/C iso2 (Ser406)lamin A/C (Ser404)
lamin A/C (Ser406)Lck (Tyr394)LOC647000 (Ser41)MEK1 (Ser218)
MEK1 (Ser222)MEK1 (Thr226)MEK2 (Ser222)MEK2 (Ser226)
MEK2 (Thr230)MINK iso4 (Thr187)MINK (Thr187)MST3 iso2 (Thr170)
MST3 iso2 (Thr172)MST3 iso2 (Thr178)MST3 iso2 (Thr182)MST3 (Thr182)
MST3 (Thr184)MST3 (Thr190)MST3 (Thr194)MST4 (Thr320)
MST4 (Thr327)mTOR (Ser2442)mTOR (Ser2448)mTOR (Ser2450)
mTOR (Ser2454)mTOR (Ser2478)mTOR (Ser2481)mTOR (Thr2444)
mTOR (Thr2446)mTOR (Thr2471)mTOR (Thr2473)mTOR (Thr2474)
mTOR (Tyr2449)MYPT1 (Ser802)MYPT1 (Ser910)MYPT1 (Thr453)
MYPT1 (Tyr446)MYPT1 (Tyr766)MYPT1 (Tyr901)MYPT1 (Tyr911)
NDRG1 (Ser344)NDRG1 (Ser352)NDRG1 (Ser354)NDRG1 (Ser357)
NDRG1 (Ser362)NDRG1 (Ser364)NDRG1 (Ser367)NDRG1 (Ser378)
NDRG1 (Ser384)NDRG1 (Ser389)NDRG1 (Ser393)NDRG1 (Thr346)
NDRG1 (Thr356)NDRG1 (Thr360)NDRG1 (Thr366)NDRG1 (Thr375)
NF-GMB iso2 (Ser134)NF-GMB iso2 (Tyr131)NF-GMB (Ser134)NF-GMB (Tyr131)
NF-κB p105 (Ser907)NRas (Tyr32)NRas (Tyr64)Nur77 (Ser351)
Nur77 (Ser360)PAK2 (Ser19)PAK2 (Ser20)PAK2 (Ser32)
PAK2 (Ser36)PAK2 (Ser42)PAK2 (Thr21)PAK2 (Thr25)
PAR-4 (Ser231)PAR-4 (Ser233)PAR-4 (Thr229)PAR-4 (Tyr177)
PDK1 iso2 (Ser114)PDK1 (Ser241)PDPK2 (Ser214)PIK3CA (Ser507)
PIK3CA (Ser509)PIK3R1 (Tyr467)PIK3R2 (Tyr464)PIK3R3 (Tyr199)
PIK3R5 (Ser507)PIK4CB iso2 (Ser256)PIK4CB (Ser256)PKA RI-α (Ser375)
PKCα (Thr494)PKCα (Thr497)PKCα (Tyr504)PKCβ iso2 (Thr498)
PKCβ iso2 (Thr500)PKCβ (Thr498)PKCβ (Thr500)PKCI (Thr412)
PKD2 (Ser375)PRAS40 (Ser203)PRAS40 (Thr266)PTEN (Ser385)
RANBP3 iso3 (Ser57)RANBP3 iso3 (Ser58)RANBP3 iso3 (Thr56)RANBP3 iso3 (Thr60)
RANBP3 (Ser125)RANBP3 (Ser126)RANBP3 (Thr124)RANBP3 (Thr128)
Raptor (Ser719)Raptor (Ser722)Rictor (Ser1320)RSK2 (Ser386)
S6 (Ser235)S6 (Ser236)S6 (Ser240)S6 (Ser242)
S6 (Ser244)S6 (Ser246)S6 (Ser247)S6 (Thr241)
SGK3 (Ser315)SGK3 (Thr318)Shb (Ser323)Shb (Tyr336)
SHIP-2 (Tyr886)Src (Tyr419)TUBA1A (Ser287)TUBA1B (Ser287)
TUBA3C (Ser287)TUBA3D (Ser287)TUBA3E (Ser287)TUBA4A (Ser287)
TUBB2A (Ser339)TUBB2B (Ser339)TUBB2C (Ser339)TUBB3 (Ser339)
TUBB4 (Ser339)TUBB6 (Ser339)TUBB (Ser339)XIAP (Ser123)
YB-1 (Ser102)YB-1 (Thr108)YB-1 (Tyr99)Yes (Tyr426)
YSK1 (Thr166)YSK1 (Thr168)YSK1 (Thr174)YSK1 (Thr178)

PTMScan® Direct Apoptosis & Autophagy

PTMScan® Direct Apoptosis/Autophagyサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、アポトーシス/オートファジー経路の構成タンパク質とその関連タンパク質に狙いを絞ったスクリーニングと定量が可能になります。

PTMScan Direct Apoptosis or Autophagy Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Apoptosis / Autophagy Protein Sites
Apoptosis / Autophagy Protein Sites
α-TubulinAkt1Akt1 (Ser473)Akt1 (Ser477)
Akt1 (Thr305)Akt1 (Thr308)Akt1 (Thr312)Akt1 (Thr479)
Akt1 (Tyr315)Akt1 (Tyr474)Akt2 (Ser302)Akt2 (Thr306)
Akt2 (Thr309)Akt2 (Thr313)Akt2 (Tyr316)Akt3 (Ser472)
Akt3 (Ser474)Akt3 (Ser476)Akt3 (Thr302)Akt3 (Thr305)
Akt3 (Thr309)Akt3 (Tyr473)ANXA5API5
ARCATG12ATG12 (Ser41)ATG12 (Thr30)
ATG3ATG4CATG7ATG9A
β-ActinBAD (Ser97)BAD (Ser99)Bak1
Bcl-11BBcl-9LBcl-9L (Thr1370)Bcl-xL
BidBIRC6Casp2Casp3
Casp3 (Asp175)Casp3 (Ser176)Casp6Casp6 (Asp179)
Casp7Casp7 (Asp198)Casp7 (Ser199)Casp8 (Asp374)
Casp9Casp9 (Asp315)Casp9 (Ser302)Casp9 (Ser307)
CCAR1CCDC72CIAPIN1CLU
CYC1CYCSDBC-1DBC-1 (Ser124)
DDAH2DNA-PKERK1 (Thr198)ERK1 (Thr202)
ERK1 (Tyr204)ERK2 (Thr181)ERK2 (Thr185)ERK2 (Thr190)
ERK2 (Tyr187)FasFas (Asp269)FYCO1
G6PIGAPDHGRP94GSK3A (Thr19)
H3HELLSIκBα (Ser32)IκBα (Ser36)
IκBα (Tyr42)IκBε (Ser18)IκBε (Ser22)IκBε (Ser25)
IKKβJun (Ser58)Jun (Ser63)Jun (Ser73)
Jun (Thr62)JunD (Ser100)JunD (Ser90)LDH-A
MIFMMRP19mTORmTOR (Ser2478)
mTOR (Ser2481)mTOR (Thr2471)mTOR (Thr2473)mTOR (Thr2474)
MycNF-κB p105NF-κB p105 (Ser923)NF-κB p105 (Ser927)
NF-κB p105 (Ser932)NF-κB p65NF-κB p65 (Asp512)NF-κB p65 (Ser536)
Nik (Thr764)Nudt2p400PAR-4 (Asp131)
PARP1PDCD10PDCD5PDCD8
PDCL3PHLDA1PI4K2A (Thr76)PIK3C2A
PIK3C3PIK3CAPIK3CA (Ser507)PIK3CA (Tyr508)
PIK3CBPIK3CDPIK4CAPIP5K2A
PKCAPKCA (Thr494)PKCA (Thr501)PKCB
PKCB (Thr497)PKCB (Thr500)PKCB (Thr504)PKCB (Tyr507)
PKCHPKCT (Thr275)PKD1 (Ser473)PKD1 (Ser738)
PKD2 (Ser706)PKD3 (Ser731)PRAS40PRAS40 (Ser203)
PRAS40 (Thr266)RABGAP1RaptorRaptor (Ser877)
Raptor (Ser886)Raptor (Thr883)Raptor (Thr889)Rictor
ROCK1ROCK2RUSC1SH3GLB1
SH3GLB2SHP-2SHP-2 (Ser580)SHP-2 (Tyr584)
SOD1STAG1SurvivinSurvivin (Asp72)
TNF-R1ULK1 (Ser556)ULK4 (Thr645)XIAP
ZNF768 (Ser17)ZNF768 (Ser18)ZNF768 (Ser23) 

PTMScan® Direct Cell Cycle & DNA Damage

PTMScan® Direct Cell Cycle and DNA Damageサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、DNAダメージと細胞周期制御の関連タンパク質に狙いを絞ったスクリーニングと定量が可能になります。

PTMScan Direct Cell Cycle & DNA Damage Pathway Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Cell Cycle & DNA Damage Protein Sites
Cell Cycle & DNA Damage Protein Sites
53BP153BP1 (Ser265)α-tubulinAPE1
ATMATM (Ser1981)ATM (Ser1983)ATR
ATR (Ser428)ATRIPAurA (Thr287)AurA (Thr288)
AurA (Thr292)AurBAurB (Thr232)AurB (Thr236)
AurB (Tyr239)AurC (Thr198)AurC (Thr202)AurC (Tyr205)
β-ActinBLMBLM (Ser74)BRCA2 (Thr77)
Bub3Bub3 (Ser135)Bub3 (Thr133)CBP
CCND1 (Thr286)CCND1 (Thr288)CCNE1CCNK iso3
CCNL1 (Ser372)CCNL1 (Ser374)CCNL1 (Tyr376)CCNT1 (Ser626)
CCNYL1CDC123Cdc16Cdc23
Cdc25BCdc25CCdc25C (Ser191)Cdc25C (Ser198)
Cdc27Cdc37Cdc42CDC45L
CDCA7 (Thr213)CDK1CDK1 (Thr14)CDK1 (Tyr15)
CDK1 (Tyr19)CDK10CDK11CDK2
CDK2 (Thr14)CDK2 (Tyr15)CDK3CDK3 (Thr14)
CDK3 (Tyr15)CDK4CDK5 (Tyr15)CDK6
CDK7CDK8CHED (Ser1054)CHED (Ser1065)
CHED (Ser1066)CHED (Thr1056)CHED (Thr1058)Chk1
Chk1 (Ser296)Chk1 (Ser307)Chk1 (Ser308)Chk1 (Ser315)
Chk1 (Ser316)Chk1 (Ser317)Chk1 (Ser345)Chk1 (Ser357)
Chk1 (Thr348)Chk1 (Tyr314)Chk2Chk2 (Ser379)
DDB1DNA-PKDNA-PK (Ser3205)ERK1
ERK1 (Thr202)ERK1 (Tyr204)ERK2ERK2 (Thr185)
ERK2 (Tyr187)ERK5 (Thr219)ERK5 (Tyr221)FANCB
FANCD2FANCIGAPDHH2AX
H2AX (Ser140)H2AX (Thr137)H3JNK1 (Thr183)
JNK1 (Tyr185)JNK2 (Thr183)JNK2 (Thr188)JNK2 (Tyr185)
JNK3 (Thr221)JNK3 (Tyr223)Ku70Ku80
LOC651610LOC731751 (Ser3204)MCM2MCM3
MCM4MCM5MCM6MCM7
MKK3 (Ser253)MKK4 (Ser257)MLH1MRE11A
MSH2 (Ser717)MSH6 (Ser309)MST1 (Ser40)MST1 (Ser43)
Myt1 (Ser40)NBS1NPM1 (Ser125)NUCKS
NUCKS (Ser14)NUCKS (Ser181)NUCKS (Ser19)NuMA-1
NuMA-1 (Ser1772)NuMA-1 (Ser395)NuMA-1 (Thr1776)p300
p21Cip1p21Cip1 (Ser130)p27Kip1p27Kip1 (Ser175)
p27Kip1 (Ser178)p27Kip1 (Ser183)p27Kip1 (Thr170)p27Kip1 (Thr187)
p38α (Ser61)p38α (Thr175)p38α (Thr180)p38α (Tyr182)
p38δ (Thr180)p38δ (Tyr182)p38γ (Ser180)p38γ (Thr183)
p38γ (Tyr185)p53 (Ser392)p70S6K (Ser243)p70S6K (Thr248)
p70S6K (Thr250)p70S6K (Thr252)p70S6K (Thr256)p70S6Kb (Ser219)
p70S6Kb (Ser356)p70S6Kb (Thr226)p70S6Kb (Thr228)p70S6Kb (Thr232)
p90RSKp90RSK (Ser221)p90RSK (Thr225)p90RSK (Tyr220)
PARP1 (Ser179)PCNAPCTAIRE1 (Tyr176)PCTAIRE2 (Tyr203)
PITSLRE (Tyr449)PITSLRE B (Tyr437)PMS2 (Ser425)POLA
POLD1POLD2PRC1 (Ser500)PRC1 (Ser501)
PRC1 (Ser513)PRC1 (Ser516)PRC1 (Thr509)PRC1 (Tyr511)
Profilin-1Profilin-2Rad17RAD21
RAD21L1RAD23ARAD23BRAD54B
RAD54B (Ser867)RAD54B (Ser869)RbRb (Ser773)
Rb (Ser780)Rb (Ser788)Rb (Ser794)Rb (Ser795)
Rb (Ser807)Rb (Ser811)Rb (Ser816)Rb (Thr774)
Rb (Thr778)Rb (Thr821)Rb (Thr823)Rb (Thr826)
Rb (Tyr790)Rb (Tyr805)Rb (Tyr813)RBBP4
RBBP7RCC1RFA2RFC1 (Ser923)
RFC2RFC3RFC4RFC5
RhoQRPA1RPA3RRas
RSK2RSK2 (Ser227)RSK2 (Thr231)RSK2 (Tyr226)
RSK3RSK4RSK4 (Ser232)RSK4 (Thr236)
RSK4 (Tyr231)Smad5 (Ser57)Smad5 (Ser58)Smc5
Smc5 (Ser792)Smc5 (Ser793)SMG1 (Ser111)SMG1 (Ser121)
SMG1L (Ser111)SMG1L (Ser121)tau (Ser713)tau (Ser717)
tau (Ser721)tau (Thr720)tau (Tyr711)TOP2A
TOP2BTOPBP1XPG (Ser324)XPG (Ser697)
XPG (Ser699)XRCC1XRCC1 (Ser241)ZNF828 (Ser405)
ZNF828 (Ser505)ZNF828 (Ser507)ZNF828 (Thr403) 

PTMScan® Direct Ser/Thr Kinases

PTMScan® Direct Ser/Thr Kinasesサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、キノーム全体にわたるSer/Thrにリン酸化を受けたタンパク質に狙いを絞ったスクリーニングと定量が可能になります。

Highlighted Ser/Thr Nodes in the Human Kinome

Sample PowerPoint Summary Report

PTMScan Sample Report Icon

Sample PowerPoint Summary Report 2.0 MB

Ser/Thr Protein Sites
Ser/Thr Protein Sites
β-Actin*Akt1 (Ser473)Akt1 (Ser475)Akt1 (Thr305)
Akt1 (Thr308)Akt1 (Thr312)Akt1 (Thr479)Akt1 (Tyr315)
Akt1 (Tyr474)Akt2 (Ser302)Akt2 (Ser474)Akt2 (Ser476)
Akt2 (Ser478)Akt2 (Thr306)Akt2 (Thr309)Akt2 (Thr313)
Akt2 (Tyr316)Akt2 (Tyr475)Akt3 (Ser472)Akt3 (Ser474)
Akt3 (Ser476)Akt3 (Thr302)Akt3 (Thr305)Akt3 (Thr309)
Akt3 (Tyr473)AMPKα1 (Ser172)AMPKα1 (Ser176)AMPKα1 (Ser184)
AMPKα1 (Ser187)AMPKα1 (Ser486)AMPKα1 (Ser494)AMPKα1 (Ser496)
AMPKα1 (Thr183)AMPKα1 (Thr482)AMPKα1 (Thr488)AMPKα1 (Thr490)
AMPKα2 (Ser161)AMPKα2 (Ser165)AMPKα2 (Ser173)AMPKα2 (Ser176)
AMPKα2 (Thr172)ASK1 (Thr916)ASK1 (Thr918)ATM (Ser1981)
ATM (Ser1983)Aurora A (Thr287)Aurora A (Thr288)Aurora A (Thr292)
Aurora B (Thr232)Aurora B (Thr236)Aurora C (Thr198)Aurora C (Thr202)
Bcr (Tyr177)BMPR2 (Thr977)BMPR2 (Tyr979)Brd2 (Ser253)
Brd2 (Ser256)Brd4 (Thr942)CDK1 (Thr14)CDK1 (Tyr15)
CDK1 (Tyr19)CDK2 (Thr14)CDK2 (Tyr15)CDK2 (Tyr19)
CDK3 (Thr14)CDK3 (Tyr15)CDK3 (Tyr19)CDK5 (Tyr15)
CDK6 (Tyr24)ChaK1 (Ser1404)ChaK1 (Ser1407)CHED (Ser1225)
CHED (Ser1229)CHED (Thr1226)Chk1 (Ser296)Chk1 (Ser305)
Chk1 (Ser307)Chk1 (Ser315)Chk1 (Ser316)Chk1 (Ser317)
Chk1 (Ser343)Chk1 (Ser345)Chk1 (Ser357)Chk1 (Thr348)
Chk1 (Thr362)Chk1 (Tyr314)CKB (Thr35)CLK3 (Ser157)
CLK3 (Ser165)CLK3 (Tyr155)CLK3 (Tyr163)CLK3 (Tyr166)
CRK7 (Thr1244)CRK7 (Thr1246)dCK (Ser13)Erk1 (Thr202)
Erk1 (Thr207)Erk1 (Tyr204)Erk2 (Thr185)Erk2 (Thr190)
Erk2 (Tyr187)Erk3 (Ser363)Erk3 (Tyr357)Erk5 (Thr218)
Erk5 (Tyr220)GAPDH*GCN2 (Ser254)GCN2 (Ser258)
GCN2 (Ser261)GCN2 (Ser264)GCN2 (Ser274)GCN2 (Tyr253)
GCN2 (Tyr269)GSK-3α (Ser20)GSK-3α (Ser21)GSK-3α (Thr19)
GSK-3β (Ser13)GSK-3β (Ser25)GSK-3β (Ser9)GSK-3β (Thr8)
HGK (Ser264)HGK (Thr187)HKDC1 (Ser155)HKDC1 (Thr153)
Histone H3*ICK (Thr157)ICK (Tyr159)IKKε (Ser172)
KSR (Ser265)KSR (Thr268)KSR (Thr272)KSR2 (Thr269)
KSR2 (Thr276)LOC100133591 (Ser223)LOC651610 (Ser1859)LOC651610 (Ser1861)
LRRK1 (Thr30)LRRK2 (Ser961)MAPKAPK-2 (Thr221)MAPKAPK-2 (Thr222)
MAPKAPK-2 (Thr317)MAPKAPK-2 (Thr329)MAPKAPK-2 (Thr334)MAPKAPK-2 (Thr338)
MAPKAPK-2 (Tyr225)MAPKAPK-3 (Ser307)MAPKAPK-3 (Thr313)MAPKAPK-3 (Thr317)
MARK1 (Thr504)MARK2 (Ser592)MARK2 (Ser593)MARK2 (Ser595)
MARK2 (Thr596)MARK3 (Thr530)MEK1 (Ser218)MEK1 (Ser222)
MEK1 (Thr226)MEK2 (Ser222)MEK2 (Ser226)MEK2 (Thr230)
MINK (Thr187)MKK3 (Ser212)MKK3 (Ser218)MKK3 (Ser253)
MKK3 (Thr222)MKK3 (Tyr214)MKK3 (Tyr230)MKK4 (Ser257)
MKK4 (Thr261)MKK6 (Ser201)MKK6 (Ser207)MKK6 (Thr211)
MSK1 (Ser376)MSK1 (Ser381)MSK1 (Tyr375)MSK2 (Ser360)
MSK2 (Ser365)MSK2 (Ser634)MSK2 (Thr376)MSK2 (Tyr359)
Mst1 (Ser40)Mst1 (Ser43)Mst1 (Tyr41)Mst3 (Thr182)
Mst3 (Thr184)Mst3 (Thr190)Mst3 (Thr194)Mst4 (Thr178)
Mst4 (Thr182)mTOR (Ser178)mTOR (Ser2442)mTOR (Ser2448)
mTOR (Ser2450)mTOR (Ser2454)mTOR (Thr2444)mTOR (Thr2446)
mTOR (Tyr2449)NDK7 (Ser304)NDK7 (Thr300)NDK7 (Thr318)
NDK7 (Tyr303)NDR1 (Thr444)NDR1 (Tyr445)NDR2 (Thr442)
NDR2 (Tyr443)OSR1 (Thr185)OSR1 (Thr189)p38α (Thr175)
p38α (Thr180)p38α (Tyr182)p38γ (Thr183)p38γ (Tyr185)
p38δ (Thr180)p38δ (Tyr182)p70 S6 Kinase (Ser243)p70 S6 Kinase (Ser441)
p70 S6 Kinase (Ser447)p70 S6 Kinase (Ser452)p70 S6 Kinase (Thr248)p70 S6 Kinase (Thr250)
p70 S6 Kinase (Thr252)p70 S6 Kinase (Thr444)p70 S6 Kinase β (Ser219)p70 S6 Kinase β (Thr226)
p70 S6 Kinase β (Thr228)p90RSK (Ser221)p90RSK (Ser380)p90RSK (Thr225)
p90RSK (Tyr220)PAK4 (Ser474)PAK4 (Thr207)PAK4 (Thr478)
PAK5 (Ser602)PAK6 (Ser560)PCTAIRE1 (Ser138)PCTAIRE1 (Tyr176)
PCTAIRE2 (Tyr203)PDK1 (Ser241)PDK1 (Thr245)PDK1 (Tyr248)
PDPK2 (Ser214)PDPK2 (Thr218)PDPK2 (Tyr221)PHKA2 (Ser1015)
PHKA2 (Ser1022)PHKA2 (Ser691)PI3 Kinase p110-alpha (Ser507)PITSLRE B (Tyr437)
PITSLRE (Thr595)PITSLRE (Tyr449)PKA C-α (Thr196)PKA C-α (Thr198)
PKA C-α (Thr202)PKA C-β (Thr196)PKA C-β (Thr198)PKA C-β (Thr202)
PKA C-γ (Thr196)PKA C-γ (Thr198)PKA C-γ (Thr202)PKCα (Ser226)
PKCα (Ser657)PKCα (Thr494)PKCα (Thr495)PKCα (Thr497)
PKCα (Thr501)PKCα (Tyr504)PKCβ (Thr497)PKCβ (Thr500)
PKCβ (Thr504)PKCδ (Ser304)PKCδ (Ser506)PKCδ (Ser645)
PKCδ (Ser647)PKCδ (Ser654)PKCδ (Ser658)PKCδ (Ser664)
PKCδ (Thr507)PKCδ (Thr511)PKCδ (Tyr313)PKCδ (Tyr334)
PKCδ (Tyr514)PKCδ (Tyr646)PKCε (Ser729)PKCγ (Thr510)
PKCγ (Thr511)PKCγ (Thr514)PKCγ (Thr518)PKCι (Ser411)
PKCι (Thr409)PKCι (Thr410)PKCι (Thr412)PKCι (Thr416)
PKCθ (Thr307)PKCζ (Ser409)PKCζ (Thr407)PKCζ (Thr410)
PKM2 (Ser77)PKN1 (Ser495)PKN1 (Ser773)PKN1 (Thr772)
PKN1 (Thr774)PKN1 (Tyr768)PKN2 (Ser497)PKN2 (Ser815)
PKN2 (Thr814)PKN2 (Thr816)PKN2 (Thr820)PKN2 (Tyr810)
PKN3 (Thr718)PLK1 (Thr210)PLK1 (Thr214)PRP4 (Ser852)
PRP4 (Tyr849)PRPS1 (Ser314)PRPS1L1 (Ser314)PRPS2 (Ser314)
PYGB (Ser15)PYGB (Tyr263)A-Raf (Ser299)A-Raf (Tyr296)
A-Raf (Tyr301)A-Raf (Tyr302)B-Raf (Ser446)B-Raf (Ser447)
B-Raf (Thr440)Raf1 (Ser338)Raf1 (Ser339)Raf1 (Tyr340)
Raf1 (Tyr341)RIOK2 (Ser332)RIOK2 (Ser335)RIOK2 (Tyr366)
RIPK2 (Ser539)RSK2 (Ser227)RSK2 (Ser386)RSK2 (Thr231)
RSK2 (Tyr226)RSK4 (Ser232)RSK4 (Thr236)RSK4 (Tyr231)
JNK1 (Ser179)JNK1 (Thr183)JNK1 (Thr188)JNK1 (Tyr185)
JNK2 (Thr183)JNK2 (Thr188)JNK2 (Tyr185)JNK3 (Ser217)
JNK3 (Thr221)JNK3 (Thr226)JNK3 (Tyr223)SGK1 (Ser74)
SGK1 (Ser78)SGK1 (Ser80)SGK2 (Thr251)SGK2 (Thr253)
SgK223 (Thr203)SGK3 (Thr320)SGK3 (Thr324)smMLCK (Thr276)
SPEG (Ser378)SPEG (Ser381)SPEG (Thr375)SPAK (Thr233)
SPAK (Thr237)TAO1 (Ser181)TAO1 (Thr185)TAO2 (Ser181)
TAO3 (Ser177)TAO3 (Thr181)TBK1 (Ser172)TIF1β (Ser459)
TIF1β (Ser460)TIF1β (Tyr458)TNIK (Thr187)TTK (Thr33)
α-Tubulin*ULK1 (Ser556)WNK1 (Ser1959)YSK1 (Thr166)
YSK1 (Thr168)YSK1 (Thr174)YSK1 (Thr178)ZAK (Ser591)
ZAK (Ser610)ZAK (Ser648)ZAK (Ser649)ZAK (Thr576)
ZAK (Thr742)   

* The following targets are included as control markers for total protein: β-Actin, Histone H3, GAPDH, and α-Tubulin.

PTMScan® Direct Tyrosine Kinases

PTMScan® Direct Tyrosine Kinasesサービスによって、創薬、バイオマーカー探索、そして診断法開発に重要な、キノームのチロシンキナーゼブランチのタンパク質に狙いを絞ったスクリーニングと定量が可能になります。

PTMScan Tyrosine Kinome Coverage.

Sample Case Study Data

Note: The case studies featured below have been saved in Excel (XLS) format.

Tyrosine Protein Sites
Tyrosine Protein Sites
A6 iso2 (Tyr343)A6 (Tyr309)Abl iso2 (Tyr112)Abl iso2 (Tyr134)
Abl iso2 (Tyr147)Abl iso2 (Tyr158)Abl iso2 (Tyr191)Abl iso2 (Tyr204)
Abl iso2 (Tyr245)Abl iso2 (Tyr251)Abl iso2 (Tyr272)Abl iso2 (Tyr276)
Abl iso2 (Tyr283)Abl iso2 (Tyr412)Abl iso2 (Tyr432)Abl iso2 (Tyr488)
Abl (Tyr115)Abl (Tyr128)Abl (Tyr139)Abl (Tyr172)
Abl (Tyr185)Abl (Tyr215)Abl (Tyr226)Abl (Tyr232)
Abl (Tyr253)Abl (Tyr257)Abl (Tyr264)Abl (Tyr393)
Abl (Tyr413)Abl (Tyr469)Abl (Tyr93)Ack iso3 (Tyr596)
Ack iso3 (Tyr937)Ack iso3 (Tyr938)Ack iso3 (Tyr946)Ack (Tyr284)
Ack (Tyr518)Ack (Tyr859)Ack (Tyr860)Ack (Tyr868)
Ack (Tyr872)Ack (Tyr874)ALK (Tyr1078)ALK (Tyr1092)
ALK (Tyr1096)ALK (Tyr1131)ALK (Tyr1278)ALK (Tyr1282)
ALK (Tyr1283)ALK (Tyr1359)ALK (Tyr1507)ALK (Tyr1584)
ALK (Tyr1586)ALK (Tyr1604)Arg iso4 (Tyr125)Arg iso4 (Tyr403)
Arg (Tyr161)Arg (Tyr174)Arg (Tyr310)Arg (Tyr439)
Arg (Tyr683)Arg (Tyr718)Arg (Tyr719)Axl (Tyr696)
Axl (Tyr697)Axl (Tyr698)Axl (Tyr702)Axl (Tyr703)
Axl (Tyr726)Axl (Tyr755)Axl (Tyr759)Axl (Tyr866)
Blk (Tyr181)Blk (Tyr182)Blk (Tyr187)Blk (Tyr188)
Blk (Tyr389)Blk (Tyr494)Blk (Tyr501)Brk (Tyr114)
Brk (Tyr447)Btk (Tyr223)Btk (Tyr225)Btk (Tyr334)
Btk (Tyr344)Btk (Tyr361)Btk (Tyr375)Btk (Tyr511)
Btk (Tyr551)CCK4 (Tyr872)CLK3 (Tyr163)CSFR (Tyr556)
CSFR (Tyr699)CSFR (Tyr809)CSK (Tyr263)DDR1 (Tyr484)
DDR1 (Tyr513)DDR1 (Tyr520)DDR1 (Tyr790)DDR1 (Tyr792)
DDR1 (Tyr794)DDR1 (Tyr796)DDR1 (Tyr797)DDR1 (Tyr869)
DDR1 (Tyr881)DDR2 (Tyr471)DDR2 (Tyr481)DDR2 (Tyr521)
DDR2 (Tyr735)DDR2 (Tyr736)DDR2 (Tyr739)DDR2 (Tyr740)
DDR2 (Tyr741)DYRK1A iso2 (Tyr136)DYRK1A iso2 (Tyr312)DYRK1A iso4 (Tyr145)
DYRK1A iso4 (Tyr321)DYRK1A (Tyr145)DYRK1A (Tyr321)DYRK1B (Tyr273)
DYRK2 (Tyr382)DYRK3 (Tyr369)DYRK4 (Tyr264)EGFR (Tyr1016)
EGFR (Tyr1069)EGFR (Tyr1092)EGFR (Tyr1110)EGFR (Tyr1125)
EGFR (Tyr1138)EGFR (Tyr1172)EGFR (Tyr1197)EGFR (Tyr727)
EGFR (Tyr827)EGFR (Tyr869)EGFR (Tyr998)EphA1 (Tyr599)
EphA1 (Tyr605)EphA1 (Tyr781)EphA2 (Tyr575)EphA2 (Tyr588)
EphA2 (Tyr589)EphA2 (Tyr594)EphA2 (Tyr595)EphA2 (Tyr628)
EphA2 (Tyr694)EphA2 (Tyr735)EphA2 (Tyr772)EphA2 (Tyr773)
EphA2 (Tyr921)EphA2 (Tyr922)EphA2 (Tyr930)EphA2 (Tyr960)
EphA3 (Tyr123)EphA3 (Tyr124)EphA3 (Tyr596)EphA3 (Tyr602)
EphA3 (Tyr736)EphA3 (Tyr779)EphA3 (Tyr937)EphA4 (Tyr596)
EphA4 (Tyr602)EphA4 (Tyr779)EphA4 (Tyr798)EphA5 (Tyr650)
EphA5 (Tyr656)EphA5 (Tyr672)EphA5 (Tyr790)EphA5 (Tyr833)
EphA6 (Tyr787)EphA6 (Tyr849)EphA7 (Tyr608)EphA7 (Tyr614)
EphA7 (Tyr791)EphB1 (Tyr575)EphB1 (Tyr582)EphB1 (Tyr594)
EphB1 (Tyr600)EphB1 (Tyr634)EphB1 (Tyr778)EphB1 (Tyr798)
EphB2 iso2 (Tyr596)EphB2 iso2 (Tyr602)EphB2 iso2 (Tyr780)EphB2 (Tyr175)
EphB2 (Tyr181)EphB2 (Tyr194)EphB2 (Tyr577)EphB2 (Tyr584)
EphB2 (Tyr585)EphB2 (Tyr592)EphB2 (Tyr596)EphB2 (Tyr602)
EphB2 (Tyr604)EphB2 (Tyr610)EphB2 (Tyr780)EphB2 (Tyr788)
EphB2 (Tyr912)EphB3 (Tyr593)EphB3 (Tyr595)EphB3 (Tyr600)
EphB3 (Tyr603)EphB3 (Tyr608)EphB3 (Tyr609)EphB3 (Tyr614)
EphB3 (Tyr754)EphB3 (Tyr787)EphB3 (Tyr792)EphB3 (Tyr812)
EphB3 (Tyr919)EphB3 (Tyr924)EphB4 (Tyr574)EphB4 (Tyr581)
EphB4 (Tyr590)EphB4 (Tyr596)EphB4 (Tyr614)EphB4 (Tyr774)
EphB4 (Tyr906)EphB4 (Tyr987)EphB6 (Tyr628)EphB6 (Tyr635)
EphB6 (Tyr637)EphB6 (Tyr638)EphB6 (Tyr644)EphB6 (Tyr645)
EphB6 (Tyr651)FAK iso2 (Tyr216)FAK iso2 (Tyr226)FAK iso2 (Tyr418)
FAK iso2 (Tyr424)FAK iso2 (Tyr425)FAK iso3 (Tyr397)FAK iso3 (Tyr407)
FAK iso3 (Tyr570)FAK iso3 (Tyr576)FAK iso3 (Tyr577)FAK iso3 (Tyr861)
FAK (Tyr397)FAK (Tyr407)FAK (Tyr441)FAK (Tyr570)
FAK (Tyr576)FAK (Tyr577)FAK (Tyr608)FAK (Tyr614)
FAK (Tyr615)FAK (Tyr861)FAK (Tyr899)FAK (Tyr925)
FAK (Tyr936)Fer (Tyr402)Fer (Tyr714)Fer (Tyr715)
Fes (Tyr156)Fes (Tyr713)FGFR1 (Tyr154)FGFR1 (Tyr583)
FGFR1 (Tyr585)FGFR1 (Tyr653)FGFR1 (Tyr654)FGFR1 (Tyr730)
FGFR2 (Tyr466)FGFR2 (Tyr586)FGFR2 (Tyr588)FGFR2 (Tyr656)
FGFR2 (Tyr657)FGFR2 (Tyr805)FGFR2 (Tyr812)FGFR3 (Tyr577)
FGFR3 (Tyr647)FGFR3 (Tyr648)FGFR4 iso3 (Tyr874)FGFR4 iso3 (Tyr875)
FGFR4 (Tyr642)FGFR4 (Tyr643)Fgr (Tyr180)Fgr (Tyr208)
Fgr (Tyr209)Fgr (Tyr28)Fgr (Tyr34)Fgr (Tyr412)
Fgr (Tyr523)FLT3 (Tyr589)FLT3 (Tyr726)FLT3 (Tyr842)
FLT3 (Tyr969)FRK (Tyr104)FRK (Tyr132)FRK (Tyr221)
FRK (Tyr317)FRK (Tyr368)FRK (Tyr387)FRK (Tyr46)
FRK (Tyr497)FRK (Tyr504)FRK (Tyr53)FRK (Tyr99)
Fyn iso2 (Tyr213)Fyn iso2 (Tyr214)Fyn iso2 (Tyr417)Fyn (Tyr185)
Fyn (Tyr213)Fyn (Tyr214)Fyn (Tyr28)Fyn (Tyr339)
Fyn (Tyr420)Fyn (Tyr440)Fyn (Tyr531)Hck (Tyr207)
Hck (Tyr209)Hck (Tyr330)Hck (Tyr409)Hck (Tyr411)
Hck (Tyr51)Hck (Tyr520)Hck (Tyr522)HER2 (Tyr1005)
HER2 (Tyr1127)HER2 (Tyr1139)HER2 (Tyr1248)HER2 (Tyr735)
HER2 (Tyr877)HER2 (Tyr878)HER3 (Tyr1054)HER3 (Tyr1156)
HER3 (Tyr1159)HER3 (Tyr1197)HER3 (Tyr1199)HER3 (Tyr1262)
HER3 (Tyr1276)HER3 (Tyr1286)HER3 (Tyr1289)HER3 (Tyr1307)
HER3 (Tyr1325)HER3 (Tyr1328)HER4 (Tyr1056)HER4 (Tyr1128)
HER4 (Tyr1134)HER4 (Tyr1268)HER4 (Tyr1284)HER4 (Tyr733)
IGF1R (Tyr1161)IGF1R (Tyr1163)IGF1R (Tyr1165)IGF1R (Tyr1166)
IGF1R (Tyr1167)IGF1R (Tyr1168)IGF1R (Tyr1346)IGF1R (Tyr1352)
IGF1R (Tyr577)IGF1R (Tyr580)InsR iso2 (Tyr1173)InsR iso2 (Tyr1177)
InsR iso2 (Tyr1178)InsR iso2 (Tyr1343)InsR iso2 (Tyr1349)InsR (Tyr1149)
InsR (Tyr1175)InsR (Tyr1179)InsR (Tyr1180)InsR (Tyr1185)
InsR (Tyr1189)InsR (Tyr1190)InsR (Tyr1345)InsR (Tyr1351)
InsR (Tyr1355)InsR (Tyr1361)ITK (Tyr146)ITK (Tyr180)
ITK (Tyr198)ITK (Tyr273)ITK (Tyr40)ITK (Tyr512)
JAK1 (Tyr1033)JAK1 (Tyr1034)JAK1 (Tyr1035)JAK1 (Tyr220)
JAK2 (Tyr1007)JAK2 (Tyr1008)JAK2 (Tyr570)JAK2 (Tyr790)
JAK2 (Tyr813)JAK2 (Tyr931)JAK2 (Tyr940)JAK2 (Tyr956)
JAK2 (Tyr966)JAK3 (Tyr785)Kit (Tyr578)Kit (Tyr703)
Kit (Tyr721)Kit (Tyr730)Kit (Tyr936)Lck (Tyr192)
Lck (Tyr394)Lck (Tyr505)Lmr2 (Tyr1100)Lmr2 (Tyr1448)
Lmr2 (Tyr1468)Lmr3 (Tyr156)LTK (Tyr672)LTK (Tyr676)
LTK (Tyr677)Lyn iso2 (Tyr172)Lyn iso2 (Tyr173)Lyn iso2 (Tyr376)
Lyn iso2 (Tyr487)Lyn (Tyr117)Lyn (Tyr193)Lyn (Tyr194)
Lyn (Tyr265)Lyn (Tyr266)Lyn (Tyr306)Lyn (Tyr316)
Lyn (Tyr32)Lyn (Tyr397)Lyn (Tyr460)Lyn (Tyr473)
Lyn (Tyr501)Lyn (Tyr508)Mer (Tyr549)Mer (Tyr744)
Mer (Tyr748)Mer (Tyr749)Mer (Tyr753)Mer (Tyr754)
Mer (Tyr929)Met (Tyr1003)Met (Tyr1093)Met (Tyr1228)
Met (Tyr1230)Met (Tyr1232)Met (Tyr1233)Met (Tyr1234)
Met (Tyr1235)Met (Tyr1349)Met (Tyr1356)Met (Tyr1365)
NPM-ALK (Tyr138)NPM-ALK (Tyr152)NPM-ALK (Tyr156)NPM-ALK (Tyr191)
NPM-ALK (Tyr338)NPM-ALK (Tyr567)NPM-ALK (Tyr644)NPM-ALK (Tyr646)
NPM-ALK (Tyr664)PDGFRa (Tyr1018)PDGFRa (Tyr572)PDGFRa (Tyr574)
PDGFRa (Tyr613)PDGFRa (Tyr731)PDGFRa (Tyr742)PDGFRa (Tyr754)
PDGFRa (Tyr762)PDGFRa (Tyr768)PDGFRa (Tyr849)PDGFRa (Tyr944)
PDGFRa (Tyr958)PDGFRa (Tyr962)PDGFRa (Tyr988)PDGFRb (Tyr739)
PDGFRb (Tyr771)PDGFRb (Tyr778)PIK3C2A (Tyr73)PIK3C2B (Tyr1056)
PIK3C2B (Tyr127)PIK3C2B (Tyr1541)PIK3C2B (Tyr228)PIK3C2B (Tyr68)
PIK3C2G (Tyr1437)PIK3CA (Tyr317)PIK3CA (Tyr508)PIK3CB (Tyr246)
PIK3CB (Tyr425)PIK3CB (Tyr503)PIK3CB (Tyr504)PIK3CB (Tyr505)
PIK3CB (Tyr772)PIK3CB (Tyr956)PIK3CB (Tyr962)PIK3CD (Tyr484)
PIK3CD (Tyr485)PIK3CD (Tyr524)PIK3CD (Tyr935)PIK3CD (Tyr936)
PIK3CG (Tyr757)PIK3R1 (Tyr368)PIK3R1 (Tyr452)PIK3R1 (Tyr463)
PIK3R1 (Tyr467)PIK3R1 (Tyr470)PIK3R1 (Tyr508)PIK3R1 (Tyr528)
PIK3R1 (Tyr556)PIK3R1 (Tyr580)PIK3R1 (Tyr607)PIK3R2 (Tyr365)
PIK3R2 (Tyr443)PIK3R2 (Tyr449)PIK3R2 (Tyr453)PIK3R2 (Tyr458)
PIK3R2 (Tyr461)PIK3R2 (Tyr464)PIK3R2 (Tyr467)PIK3R2 (Tyr505)
PIK3R2 (Tyr599)PIK3R2 (Tyr605)PIK3R3 (Tyr195)PIK3R3 (Tyr199)
PIK3R3 (Tyr202)PIK3R3 (Tyr341)PIK4CA iso3 (Tyr1059)PIK4CA iso3 (Tyr1182)
PIK4CA iso3 (Tyr556)PIK4CA iso3 (Tyr719)PIK4CA (Tyr1096)PIK4CA (Tyr1745)
PIK4CA (Tyr2032)PIK4CA (Tyr470)PIK4CA (Tyr633)PIK4CA (Tyr973)
PIP5K1A iso2 (Tyr129)PIP5K1A iso2 (Tyr333)PIP5K1A iso2 (Tyr347)PIP5K1A (Tyr142)
PIP5K1A (Tyr346)PIP5K1A (Tyr360)PIP5K1A (Tyr483)PIP5K2A (Tyr246)
PIP5K2A (Tyr93)PIP5K2B (Tyr167)PIP5K2B (Tyr197)PIP5K2B (Tyr98)
PIP5KG (Tyr136)PIP5K (Tyr154)PIP5K (Tyr1772)PIP5K (Tyr1773)
PIP5K (Tyr324)Pyk2 iso2 (Tyr579)Pyk2 iso2 (Tyr580)Pyk2 iso2 (Tyr777)
Pyk2 (Tyr402)Pyk2 (Tyr579)Pyk2 (Tyr580)Pyk2 (Tyr683)
Pyk2 (Tyr699)Pyk2 (Tyr722)Pyk2 (Tyr819)Pyk2 (Tyr849)
Ret (Tyr1062)Ret (Tyr1096)Ret (Tyr687)Ret (Tyr900)
Ret (Tyr905)Ron (Tyr1238)Ron (Tyr1239)Ron (Tyr1353)
Ron (Tyr1360)ROR1 (Tyr160)ROR1 (Tyr173)ROR1 (Tyr786)
ROR1 (Tyr789)ROR1 (Tyr828)ROR1 (Tyr836)ROR2 (Tyr666)
ROR2 (Tyr873)ROS (Tyr1535)ROS (Tyr1923)ROS (Tyr2110)
ROS (Tyr2114)ROS (Tyr2115)ROS (Tyr2274)ROS (Tyr2323)
ROS (Tyr2334)ROS (Tyr2342)Src (Tyr187)Src (Tyr216)
Src (Tyr419)Src (Tyr424)Src (Tyr439)Src (Tyr444)
Src (Tyr530)Src (Tyr535)Syk (Tyr203)Syk (Tyr244)
Syk (Tyr296)Syk (Tyr317)Syk (Tyr323)Syk (Tyr342)
Syk (Tyr346)Syk (Tyr348)Syk (Tyr352)Syk (Tyr47)
Syk (Tyr525)Syk (Tyr526)Syk (Tyr568)Syk (Tyr630)
Syk (Tyr631)Syk (Tyr74)TEC (Tyr228)TEC (Tyr233)
TEC (Tyr518)TIE2 (Tyr897)Tnk1 (Tyr661)TrkA iso2 (Tyr670)
TrkA (Tyr676)TrkA (Tyr680)TrkA (Tyr681)TrkA (Tyr791)
TrkC iso2 (Tyr516)TrkC iso2 (Tyr597)TrkC iso2 (Tyr604)TrkC (Tyr516)
TTK (Tyr374)TTK (Tyr462)TTK (Tyr833)TTK (Tyr836)
Tyk2 (Tyr1054)Tyk2 (Tyr1145)Tyk2 (Tyr291)Tyk2 (Tyr292)
Tyk2 (Tyr433)Tyk2 (Tyr827)Tyro3 (Tyr671)Tyro3 (Tyr675)
Tyro3 (Tyr681)Tyro3 (Tyr685)Tyro3 (Tyr686)Tyro3 (Tyr828)
VEGFR-1 (Tyr1048)VEGFR-1 (Tyr1053)VEGFR-1 (Tyr1213)VEGFR-1 (Tyr1242)
VEGFR-1 (Tyr383)VEGFR-1 (Tyr388)VEGFR-1 (Tyr794)VEGFR-2 (Tyr1054)
VEGFR-2 (Tyr1059)VEGFR-2 (Tyr1214)VEGFR-3 (Tyr1063)VEGFR-3 (Tyr1068)
Yes (Tyr141)Yes (Tyr146)Yes (Tyr159)Yes (Tyr194)
Yes (Tyr220)Yes (Tyr221)Yes (Tyr222)Yes (Tyr223)
Yes (Tyr32)Yes (Tyr343)Yes (Tyr345)Yes (Tyr424)
Yes (Tyr426)Yes (Tyr444)Yes (Tyr446)Yes (Tyr535)
Yes (Tyr537)ZAP70 (Tyr164)ZAP70 (Tyr178)ZAP70 (Tyr248)
ZAP70 (Tyr292)ZAP70 (Tyr315)ZAP70 (Tyr319)ZAP70 (Tyr46)
ZAP70 (Tyr474)ZAP70 (Tyr492)ZAP70 (Tyr493)ZAP70 (Tyr597)
ZAP70 (Tyr598)ZAP70 (Tyr69)ZAP70 (Tyr87) 

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